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External Self‐Closing Tube to Occlude a Vessel Gradually as a Therapeutic Means of Portosystemic Shunt

 Tae Young Kim  ;  Dae‐Hyun Kim  ;  Jeong‐Kee Yoon  ;  Surim Kim  ;  Se Won Yi  ;  Won Taek Oh  ;  Ju Young Park  ;  Hye‐Seon Kim  ;  Mi‐Lan Kang  ;  Jung Bok Lee  ;  Hak‐Joon Sung 
 ADVANCED THERAPEUTICS, Vol.3(8) : 2000039, 2020-08 
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The vascular network to the liver can be connected abnormally during fetal development (e.g., portosystemic shunt), thus requiring a device to close the flow connection completely. Gradual vascular occlusion is particularly important, because a sudden stop in blood flow can result in portal hypertension and cause consequential damage to the small intestine. Significant progress has been made in the development of such devices (e.g., the ameroid ring constrictor and cellophane banding) as a standard treatment for this disorder. However, incomplete occlusion is a common problem. In this study, a new vascular occlusion device is developed, enabling two major functions. First, user‐friendly deployment onto the external vascular wall is achieved by programming a recovery in the shape of the tube from open to closed in response to treatment with a warm saline solution (37 °C). Second, proinflammatory palmitic acid is released over time from the tube surface through the adventitial wall to induce gradual occlusive vascular remodeling. These unprecedented functions are demonstrated in a series of experiments on cells and rabbit veins, addressing this major issue through gradual but complete vascular occlusion over time. The external self‐closing tube represents a breakthrough proof‐of‐concept for treatment of this rare but critical developmental disorder.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Kang, Mi-Lan(강미란)
Kim, Dae-Hyun(김대현)
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
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