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Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction

Authors
 F Saverio Bersani  ;  Synthia H Mellon  ;  Daniel Lindqvist  ;  Jee In Kang  ;  Ryan Rampersaud  ;  Pramod Rajaram Somvanshi  ;  Francis J Doyle  ;  Rasha Hammamieh  ;  Marti Jett  ;  Rachel Yehuda  ;  Charles R Marmar  ;  Owen M Wolkowitz 
Citation
 MILITARY MEDICINE, Vol.185(Suppl 1) : 313-318, 2020-01 
Journal Title
 MILITARY MEDICINE 
ISSN
 0026-4075 
Issue Date
2020-01
MeSH
Combat Disorders / drug therapy* ; Combat Disorders / physiopathology ; Gastrointestinal Microbiome / drug effects* ; Gastrointestinal Microbiome / physiology ; Humans ; Inflammation / drug therapy* ; Inflammation / physiopathology ; Metabolism / drug effects* ; Metabolism / physiology ; Mitochondria / drug effects ; Mitochondria / metabolism ; Pharmacological Phenomena / physiology
Abstract
Introduction: Current pharmacological treatments of post-traumatic stress disorder (PTSD) have limited efficacy. Although the diagnosis is based on psychopathological criteria, it is frequently accompanied by somatic comorbidities and perhaps "accelerated biological aging," suggesting widespread physical concomitants. Such physiological comorbidities may affect core PTSD symptoms but are rarely the focus of therapeutic trials. Methods: To elucidate the potential involvement of metabolism, inflammation, and mitochondrial function in PTSD, we integrate findings and mechanistic models from the DOD-sponsored "Systems Biology of PTSD Study" with previous data on these topics. Results: Data implicate inter-linked dysregulations in metabolism, inflammation, mitochondrial function, and perhaps the gut microbiome in PTSD. Several inadequately tested targets of pharmacological intervention are proposed, including insulin sensitizers, lipid regulators, anti-inflammatories, and mitochondrial biogenesis modulators. Conclusions: Systemic pathologies that are intricately involved in brain functioning and behavior may not only contribute to somatic comorbidities in PTSD, but may represent novel targets for treating core psychiatric symptoms.
Full Text
https://academic.oup.com/milmed/article/185/Supplement_1/311/5740670
DOI
10.1093/milmed/usz260
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180217
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