Cited 24 times in
Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction
DC Field | Value | Language |
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dc.contributor.author | 강지인 | - |
dc.date.accessioned | 2020-12-01T17:19:18Z | - |
dc.date.available | 2020-12-01T17:19:18Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0026-4075 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180217 | - |
dc.description.abstract | Introduction: Current pharmacological treatments of post-traumatic stress disorder (PTSD) have limited efficacy. Although the diagnosis is based on psychopathological criteria, it is frequently accompanied by somatic comorbidities and perhaps "accelerated biological aging," suggesting widespread physical concomitants. Such physiological comorbidities may affect core PTSD symptoms but are rarely the focus of therapeutic trials. Methods: To elucidate the potential involvement of metabolism, inflammation, and mitochondrial function in PTSD, we integrate findings and mechanistic models from the DOD-sponsored "Systems Biology of PTSD Study" with previous data on these topics. Results: Data implicate inter-linked dysregulations in metabolism, inflammation, mitochondrial function, and perhaps the gut microbiome in PTSD. Several inadequately tested targets of pharmacological intervention are proposed, including insulin sensitizers, lipid regulators, anti-inflammatories, and mitochondrial biogenesis modulators. Conclusions: Systemic pathologies that are intricately involved in brain functioning and behavior may not only contribute to somatic comorbidities in PTSD, but may represent novel targets for treating core psychiatric symptoms. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Association of Military Surgeons | - |
dc.relation.isPartOf | MILITARY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Combat Disorders / drug therapy* | - |
dc.subject.MESH | Combat Disorders / physiopathology | - |
dc.subject.MESH | Gastrointestinal Microbiome / drug effects* | - |
dc.subject.MESH | Gastrointestinal Microbiome / physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation / drug therapy* | - |
dc.subject.MESH | Inflammation / physiopathology | - |
dc.subject.MESH | Metabolism / drug effects* | - |
dc.subject.MESH | Metabolism / physiology | - |
dc.subject.MESH | Mitochondria / drug effects | - |
dc.subject.MESH | Mitochondria / metabolism | - |
dc.subject.MESH | Pharmacological Phenomena / physiology | - |
dc.title | Novel Pharmacological Targets for Combat PTSD-Metabolism, Inflammation, The Gut Microbiome, and Mitochondrial Dysfunction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | F Saverio Bersani | - |
dc.contributor.googleauthor | Synthia H Mellon | - |
dc.contributor.googleauthor | Daniel Lindqvist | - |
dc.contributor.googleauthor | Jee In Kang | - |
dc.contributor.googleauthor | Ryan Rampersaud | - |
dc.contributor.googleauthor | Pramod Rajaram Somvanshi | - |
dc.contributor.googleauthor | Francis J Doyle | - |
dc.contributor.googleauthor | Rasha Hammamieh | - |
dc.contributor.googleauthor | Marti Jett | - |
dc.contributor.googleauthor | Rachel Yehuda | - |
dc.contributor.googleauthor | Charles R Marmar | - |
dc.contributor.googleauthor | Owen M Wolkowitz | - |
dc.identifier.doi | 10.1093/milmed/usz260 | - |
dc.contributor.localId | A00084 | - |
dc.relation.journalcode | J03027 | - |
dc.identifier.eissn | 1930-613X | - |
dc.identifier.pmid | 32074311 | - |
dc.identifier.url | https://academic.oup.com/milmed/article/185/Supplement_1/311/5740670 | - |
dc.contributor.alternativeName | Kang, Jee In | - |
dc.contributor.affiliatedAuthor | 강지인 | - |
dc.citation.volume | 185 | - |
dc.citation.number | Suppl 1 | - |
dc.citation.startPage | 313 | - |
dc.citation.endPage | 318 | - |
dc.identifier.bibliographicCitation | MILITARY MEDICINE, Vol.185(Suppl 1) : 313-318, 2020-01 | - |
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