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Relationship between Eating and Digestive Symptoms and Respiratory Function in Advanced Duchenne Muscular Dystrophy Patients

Authors
 Jang Woo Lee  ;  Hyun Jun Oh  ;  Won Ah Choi  ;  Dong Jin Kim  ;  Seong-Woong Kang 
Citation
 Journal of Neuromuscular Diseases, Vol.7(2) : 101-107, 2020-03 
Journal Title
 Journal of Neuromuscular Diseases 
ISSN
 2214-3599 
Issue Date
2020-03
MeSH
Adolescent ; Adult ; Deglutition Disorders / etiology ; Deglutition Disorders / physiopathology ; Gastrointestinal Diseases / etiology ; Gastrointestinal Diseases / physiopathology* ; Humans ; Male ; Muscular Dystrophy, Duchenne / complications ; Muscular Dystrophy, Duchenne / physiopathology* ; Noninvasive Ventilation ; Respiration Disorders / etiology ; Respiration Disorders / physiopathology* ; Respiratory Function Tests ; Retrospective Studies ; Severity of Illness Index* ; Young Adult
Keywords
Duchenne muscular dystrophy ; deglutition disorders ; digestive symptoms ; respiratory function
Abstract
Background: Duchenne muscular dystrophy (DMD) patients can have various issues that affect their quality of life, including eating and digestive conditions. Objective: We sought to identify the relationship between respiratory function and various eating and digestion related symptoms in patients with advanced Duchenne muscular dystrophy (DMD). Methods: Eating and digestive symptoms, including loss of appetite, nausea, vomiting, diarrhea, constipation, swallowing difficulty, mastication difficulty, early satiety, and aspiration, were evaluated among patients with advanced DMD who were nonambulatory and required noninvasive mechanical ventilatory support. In addition, various respiratory function parameters were measured, including forced vital capacity (FVC), maximal insufflation capacity (MIC), peak cough flow (PCF), assisted PCF (APCF), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP). We then analyzed the relationship between gastrointestinal symptoms and respiratory function parameters. Results: A total of 180 patients (age, 22.3±5.0 years) were included in the analysis. Loss of appetite and early satiety showed no correlation with any of the respiratory function parameters. Constipation was correlated with MEP; swallowing difficulty was correlated with MIC, APCF, MIP and MEP; and mastication difficulty was correlated with FVC, PCF, APCF, MIP, and MEP. Notably, age did not correlate with any gastrointestinal symptoms. Conclusions: Eating and digestive symptoms are more closely correlated with respiratory function than with age in patients with DMD. We think this correlation is mainly caused by the skeletal muscle strength, which is major determinant of both digestive and respiratory function.
Files in This Item:
T202004290.pdf Download
DOI
10.3233/JND-190435
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Choi, Won Ah(최원아) ORCID logo https://orcid.org/0000-0003-0403-8869
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180191
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