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Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Authors
 Tae-Jin Song  ;  Byung-Su Kim  ;  Min Kyung Chu 
Citation
 Progress in Brain Research, Vol.255 : 343-369, 2020-05 
Journal Title
 Progress in Brain Research 
ISSN
 0079-6123 
Issue Date
2020-05
Keywords
Circadian rhythm ; Circadian rhythm sleep disorders ; Headache ; Insomnia ; Melatonin ; Migraine
Abstract
Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.
Full Text
https://www.sciencedirect.com/science/article/pii/S007961232030056X
DOI
10.1016/bs.pbr.2020.05.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180169
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