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Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis

Authors
 Jihye Park  ;  Daeun Jeong  ;  Youn Wook Chung  ;  Da Hye Kim  ;  Jae Hee Cheon  ;  Ji Hwan Ryu 
Citation
 YONSEI MEDICAL JOURNAL, Vol.61(10) : 891-894, 2020-10 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2020-10
MeSH
Betacoronavirus ; Coronavirus Infections* ; Dipeptidyl Peptidase 4 / metabolism ; Enterocolitis* / metabolism ; Gastrointestinal Microbiome ; Humans ; Lung / metabolism ; Pandemics ; Peptidyl-Dipeptidase A / metabolism* ; Pneumonia, Viral* ; Proteomics*
Keywords
COVID-19 ; Coronavirus ; SARS-CoV-2 ; angiotensin converting enzyme 2 ; proteomics
Abstract
The cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Behćet's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.
Files in This Item:
T202004228.pdf Download
DOI
10.3349/ymj.2020.61.10.891
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Ji Hye(박지혜)
Ryu, Ji Hwan(유지환)
Chung, Youn Wook(정연욱) ORCID logo https://orcid.org/0000-0002-4382-1410
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180149
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