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Quantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis

DC Field Value Language
dc.contributor.author박지혜-
dc.contributor.author유지환-
dc.contributor.author정연욱-
dc.contributor.author천재희-
dc.date.accessioned2020-12-01T17:09:34Z-
dc.date.available2020-12-01T17:09:34Z-
dc.date.issued2020-10-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180149-
dc.description.abstractThe cellular entry of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is mediated by interaction with the human angiotensin-converting enzyme 2 (ACE2), a receptor that is expressed on both lung and intestinal epithelial cells. We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Behćet's disease (BD), and intestinal tuberculosis (TB), when compared with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD, and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBetacoronavirus-
dc.subject.MESHCoronavirus Infections*-
dc.subject.MESHDipeptidyl Peptidase 4 / metabolism-
dc.subject.MESHEnterocolitis* / metabolism-
dc.subject.MESHGastrointestinal Microbiome-
dc.subject.MESHHumans-
dc.subject.MESHLung / metabolism-
dc.subject.MESHPandemics-
dc.subject.MESHPeptidyl-Dipeptidase A / metabolism*-
dc.subject.MESHPneumonia, Viral*-
dc.subject.MESHProteomics*-
dc.titleQuantitative Proteomic Analysis of the Expression of SARS-CoV-2 Receptors in the Gut of Patients with Chronic Enterocolitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJihye Park-
dc.contributor.googleauthorDaeun Jeong-
dc.contributor.googleauthorYoun Wook Chung-
dc.contributor.googleauthorDa Hye Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorJi Hwan Ryu-
dc.identifier.doi10.3349/ymj.2020.61.10.891-
dc.contributor.localIdA04575-
dc.contributor.localIdA04611-
dc.contributor.localIdA03654-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid32975064-
dc.subject.keywordCOVID-19-
dc.subject.keywordCoronavirus-
dc.subject.keywordSARS-CoV-2-
dc.subject.keywordangiotensin converting enzyme 2-
dc.subject.keywordproteomics-
dc.contributor.alternativeNamePark, Ji Hye-
dc.contributor.affiliatedAuthor박지혜-
dc.contributor.affiliatedAuthor유지환-
dc.contributor.affiliatedAuthor정연욱-
dc.contributor.affiliatedAuthor천재희-
dc.citation.volume61-
dc.citation.number10-
dc.citation.startPage891-
dc.citation.endPage894-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.61(10) : 891-894, 2020-10-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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