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Development of a nomogram using fundus photography to predict glaucoma progression in patients showing disc hemorrhage

Authors
 Sangah Kim  ;  Chan Keum Park  ;  Eun Woo Kim  ;  Sang Yeop Lee  ;  Gong Je Seong  ;  Chan Yun Kim  ;  Hyoung Won Bae 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : 14650, 2020-09 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2020-09
Abstract
To develop a nomogram to predict the progression of glaucoma by fundus photography in patients with disc hemorrhage. Retrospective review of the medical records of patients with disc hemorrhage, which was detected during follow up with open angle glaucoma, from January 2010 to March 2018. Patients were divided into glaucoma progression (n = 52) or non-progression (n = 38) groups. We assessed proximal location and morphology of disc hemorrhage; relationship to retinal nerve fiber layer defects with disc hemorrhage; and angular extent of disc hemorrhage, between groups using fundus photography. Multiple logistic regression analysis was performed to select prognostic factors, and we constructed a nomogram to predict glaucoma progression. The number of disc hemorrhage at the border of retinal nerve fiber layer defects (P = 0.001) and peripapillary disc hemorrhage (P = 0.008) were significantly higher in the progression group. We used angular extent; location of disc hemorrhage with retinal nerve fiber layer defects; and proximal location of disc hemorrhage to construct the nomogram. The area under the receiver operating characteristic curve of the nomogram was 0.847. We created the nomogram using fundus photography in patients showing disc hemorrhage as a novel and accurate screening method to predict glaucoma progression and aid clinicians to decide on the best treatment plan.
Files in This Item:
T202003834.pdf Download
DOI
10.1038/s41598-020-71183-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sangah(김상아) ORCID logo https://orcid.org/0000-0002-8511-2903
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180049
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