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Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix

Authors
 Hera Jung  ;  Go Eun Bae  ;  Hye Min Kim  ;  Hyun-Soo Kim 
Citation
 CANCER GENOMICS & PROTEOMICS, Vol.17(5) : 627-641, 2020-09 
Journal Title
 CANCER GENOMICS & PROTEOMICS 
ISSN
 1109-6535 
Issue Date
2020-09
Keywords
Uterus ; cervix ; gastric-type mucinous carcinoma ; immunohistochemistry ; targeted sequencing ; usual-type endocervical adenocarcinoma
Abstract
Background/aim: We investigated differences in the clinicopathological and molecular characteristics between gastric-type mucinous carcinoma (GMC) and usual-type endocervical adenocarcinoma (UEA). Patients and methods: We collected the clinicopathological information and performed targeted genomic sequencing analysis. Results: GMCs exhibited significantly deeper invasion depth, larger horizontal spread, more advanced stage, more frequent distant metastasis, and more frequent parametrial and vaginal extension. Disease-free survival time of GMC patients was significantly shorter than that of UEA patients. GMCs displayed mutant p53 immunostaining pattern, whereas UEAs exhibited p16 block positivity. GMCs harbored mutations in KRAS, TP53, NF1, CDKN2A, STK11, and ARID1A. One GMC exhibited MDM2 amplification. In contrast, UEAs harbored mutations in HRAS, PIK3CA, and BRCA2. Two UEAs were found to have novel TP53 mutations. Conclusion: GMC is associated with more aggressive behavior than UEA. Distinctive p53 and p16 immunostaining patterns enable differential diagnosis. GMC and UEA exhibit genetic heterogeneity with potentially actionable molecular alterations.
Files in This Item:
T202003647.pdf Download
DOI
10.21873/cgp.20219
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180025
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