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Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix

DC FieldValueLanguage
dc.contributor.author김혜민-
dc.date.accessioned2020-12-01T16:52:47Z-
dc.date.available2020-12-01T16:52:47Z-
dc.date.issued2020-09-
dc.identifier.issn1109-6535-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180025-
dc.description.abstractBackground/aim: We investigated differences in the clinicopathological and molecular characteristics between gastric-type mucinous carcinoma (GMC) and usual-type endocervical adenocarcinoma (UEA). Patients and methods: We collected the clinicopathological information and performed targeted genomic sequencing analysis. Results: GMCs exhibited significantly deeper invasion depth, larger horizontal spread, more advanced stage, more frequent distant metastasis, and more frequent parametrial and vaginal extension. Disease-free survival time of GMC patients was significantly shorter than that of UEA patients. GMCs displayed mutant p53 immunostaining pattern, whereas UEAs exhibited p16 block positivity. GMCs harbored mutations in KRAS, TP53, NF1, CDKN2A, STK11, and ARID1A. One GMC exhibited MDM2 amplification. In contrast, UEAs harbored mutations in HRAS, PIK3CA, and BRCA2. Two UEAs were found to have novel TP53 mutations. Conclusion: GMC is associated with more aggressive behavior than UEA. Distinctive p53 and p16 immunostaining patterns enable differential diagnosis. GMC and UEA exhibit genetic heterogeneity with potentially actionable molecular alterations.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer-
dc.relation.isPartOfCANCER GENOMICS & PROTEOMICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorHera Jung-
dc.contributor.googleauthorGo Eun Bae-
dc.contributor.googleauthorHye Min Kim-
dc.contributor.googleauthorHyun-Soo Kim-
dc.identifier.doi10.21873/cgp.20219-
dc.contributor.localIdA04553-
dc.relation.journalcodeJ03713-
dc.identifier.eissn1790-6245-
dc.identifier.pmid32859641-
dc.subject.keywordUterus-
dc.subject.keywordcervix-
dc.subject.keywordgastric-type mucinous carcinoma-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordtargeted sequencing-
dc.subject.keywordusual-type endocervical adenocarcinoma-
dc.contributor.alternativeNameKim, Hye Min-
dc.contributor.affiliatedAuthor김혜민-
dc.citation.volume17-
dc.citation.number5-
dc.citation.startPage627-
dc.citation.endPage641-
dc.identifier.bibliographicCitationCANCER GENOMICS & PROTEOMICS, Vol.17(5) : 627-641, 2020-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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