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Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model

Authors
 Jung Min Kim  ;  Da Hye Kim  ;  Hyo Jeong Park  ;  Hyun Woo Ma  ;  I Seul Park  ;  Mijeong Son  ;  So Youn Ro  ;  Seokmann Hong  ;  Hyo Kyung Han  ;  Soo Jeong Lim  ;  Seung Won Kim  ;  Jae Hee Cheon 
Citation
 JOURNAL OF NANOBIOTECHNOLOGY, Vol.18(1) : 133, 2020-09 
Journal Title
 JOURNAL OF NANOBIOTECHNOLOGY 
Issue Date
2020-09
Keywords
Inflammatory bowel disease ; Infliximab ; Nanocomposite carrier ; Oral delivery system
Abstract
Background: Infliximab (IFX), a TNF-α blocking chimeric monoclonal antibody, induces clinical response and mucosal healing in patients with inflammatory bowel disease (IBD). However, systemic administration of this agent causes unwanted side effects. Oral delivery of antibody therapeutics might be an effective treatment strategy for IBD compared to intravenous administration. Results: All three carriers had a high encapsulation efficiency, narrow size distribution, and minimal systemic exposure. There was a higher interaction between nanocomposite carriers and monocytes compared to lymphocytes in the PBMC of IBD patients. Orally administered nanocomposite carriers targeted to inflamed colitis minimized systemic exposure. All IFX delivery formulations with nanocomposite carriers had a significantly less colitis-induced body weight loss, colon shortening and histomorphological score, compared to the DSS-treated group. AC-IFX-L and EAC-IFX-L groups showed significantly higher improvement of the disease activity index, compared to the DSS-treated group. In addition, AC-IFX-L and EAC-IFX-L alleviated pro-inflammatory cytokine expressions (Tnfa, Il1b, and Il17). Conclusion: We present orally administered antibody delivery systems which improved efficacy in murine colitis while reducing systemic exposure. These oral delivery systems suggest a promising therapeutic approach for treating IBD.
Files in This Item:
T202003630.pdf Download
DOI
10.1186/s12951-020-00693-4
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Won(김승원) ORCID logo https://orcid.org/0000-0002-1692-1192
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180011
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