Cited 3 times in
Radiographic portal or superior mesenteric vein invasion is an independent prognostic factor in non-metastatic pancreatic ductal adenocarcinoma: A missing block of clinical T staging?
DC Field | Value | Language |
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dc.contributor.author | 강화평 | - |
dc.contributor.author | 김승섭 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 박승우 | - |
dc.contributor.author | 박정엽 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 성민제 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 조중현 | - |
dc.date.accessioned | 2020-12-01T16:46:09Z | - |
dc.date.available | 2020-12-01T16:46:09Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1424-3903 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179965 | - |
dc.description.abstract | Background: Venous invasion is not included in the pancreatic ductal adenocarcinoma (PDAC) staging, and its correlation with prognosis remains unclear. We evaluated the prognostic impact of radiographic portal/superior mesenteric vein (PV/SMV) invasion, and its possibility of complementing T staging. Methods: We identified patients with non-metastatic PDAC using our institutional cohort, and divided them according to PV/SMV invasion at imaging, defined as >180-degree tumor-vessel interface or contour deformity. We conducted Cox proportional hazard regression, and compared survival in the original and 1:1 propensity score matched datasets. Results: We identified 454 patients [PV/SMV(+): 172; PV/SMV(-): 282]. In the multivariate analysis, PV/SMV invasion, age (≥70 years), performance status, tumor size (2-4, >4 cm), lymph nodes >4, and arterial invasion was correlated with prognosis. The PV/SMV(+) group had a shorter overall survival (OS) than the PV/SMV(-) group in the original (14.4 vs. 20.9 months; P < 0.001) and matched datasets (14.3 vs. 17.2 months; P = 0.009). Among patients without arterial invasion (cT1-cT3), the PV/SMV(+) group had a shorter OS (15.9 vs. 21.2 months; P = 0.002). Moreover, their OS did not differ from that of patients with arterial invasion (cT4) (15.9 vs. 14.4 months; P = 0.907). Patients with vessel (artery/vein) invasion had a shorter OS than those without vessel invasion (14.5 vs. 21.2 months; P < 0.001). Conclusions: Radiographic PV/SMV invasion in non-metastatic PDAC was correlated with a poor prognosis. It could identify a group with shorter OS among patients without arterial invasion (cT1-cT3). It is suggested that inclusion of PV/SMV invasion in clinical T4 criteria should be considered. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier India | - |
dc.relation.isPartOf | PANCREATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Radiographic portal or superior mesenteric vein invasion is an independent prognostic factor in non-metastatic pancreatic ductal adenocarcinoma: A missing block of clinical T staging? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Huapyong Kang | - |
dc.contributor.googleauthor | Seung-Seob Kim | - |
dc.contributor.googleauthor | Min Je Sung | - |
dc.contributor.googleauthor | Jung Hyun Jo | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.identifier.doi | 10.1016/j.pan.2020.05.017 | - |
dc.contributor.localId | A00100 | - |
dc.contributor.localId | A05097 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A01551 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A05975 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A03912 | - |
dc.relation.journalcode | J02464 | - |
dc.identifier.eissn | 1424-3911 | - |
dc.identifier.pmid | 32561070 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1424390320301861 | - |
dc.subject.keyword | Pancreatic cancer | - |
dc.subject.keyword | Portal vein | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Staging system | - |
dc.subject.keyword | Venous invasion | - |
dc.contributor.alternativeName | Kang, Huapyong | - |
dc.contributor.affiliatedAuthor | 강화평 | - |
dc.contributor.affiliatedAuthor | 김승섭 | - |
dc.contributor.affiliatedAuthor | 박미숙 | - |
dc.contributor.affiliatedAuthor | 박승우 | - |
dc.contributor.affiliatedAuthor | 박정엽 | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.contributor.affiliatedAuthor | 성민제 | - |
dc.contributor.affiliatedAuthor | 송시영 | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.contributor.affiliatedAuthor | 정문재 | - |
dc.contributor.affiliatedAuthor | 조중현 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 952 | - |
dc.citation.endPage | 959 | - |
dc.identifier.bibliographicCitation | PANCREATOLOGY, Vol.20(5) : 952-959, 2020-07 | - |
dc.identifier.rimsid | 67119 | - |
dc.type.rims | ART | - |
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