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Preferential microglial activation associated with pathological alpha synuclein transmission

Authors
 Young Eun Kim  ;  Thuy Thi Lai  ;  Yun Joong Kim  ;  Beomseok Jeon 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.81 : 469-476, 2020-11 
Journal Title
 JOURNAL OF CLINICAL NEUROSCIENCE 
ISSN
 0967-5868 
Issue Date
2020-11
Keywords
Alpha-synuclein ; Microglia ; Astrocyte ; Inflammation ; Parkinson’s disease
Abstract
Self-proliferation of the pathological form of a-synuclein was identified as one of the main pathophysiological presentations of Parkinson’s disease (PD) a decade ago. Although inflammation has also been suggested to contribute to PD pathogenesis, it is unclear whether this is associated with the pathological spread of a-synuclein aggregation. Herein, we evaluated two main neuroinflammatory processes in the striatum—microgliosis and astrogliosis—after the injection of preformed fibrils of a-synuclein into the mouse striatum. Thus, our study demonstrated that microgliosis accompanied a-synuclein propagation, while astrogliosis did not. Therefore, we report a preferential association between microglia and the process of a-synuclein proliferation.
Full Text
https://www.sciencedirect.com/science/article/pii/S096758682031506X
DOI
10.1016/j.jocn.2020.09.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yun Joong(김윤중)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179872
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