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Preferential microglial activation associated with pathological alpha synuclein transmission

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dc.contributor.author김윤중-
dc.date.accessioned2020-11-18T05:42:13Z-
dc.date.available2020-11-18T05:42:13Z-
dc.date.issued2020-11-
dc.identifier.issn0967-5868-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179872-
dc.description.abstractSelf-proliferation of the pathological form of a-synuclein was identified as one of the main pathophysiological presentations of Parkinson’s disease (PD) a decade ago. Although inflammation has also been suggested to contribute to PD pathogenesis, it is unclear whether this is associated with the pathological spread of a-synuclein aggregation. Herein, we evaluated two main neuroinflammatory processes in the striatum—microgliosis and astrogliosis—after the injection of preformed fibrils of a-synuclein into the mouse striatum. Thus, our study demonstrated that microgliosis accompanied a-synuclein propagation, while astrogliosis did not. Therefore, we report a preferential association between microglia and the process of a-synuclein proliferation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherChurchill Livingstone-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePreferential microglial activation associated with pathological alpha synuclein transmission-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorYoung Eun Kim-
dc.contributor.googleauthorThuy Thi Lai-
dc.contributor.googleauthorYun Joong Kim-
dc.contributor.googleauthorBeomseok Jeon-
dc.identifier.doi10.1016/j.jocn.2020.09.027-
dc.contributor.localIdA00796-
dc.relation.journalcodeJ01328-
dc.identifier.eissn1532-2653-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S096758682031506X-
dc.subject.keywordAlpha-synuclein-
dc.subject.keywordMicroglia-
dc.subject.keywordAstrocyte-
dc.subject.keywordInflammation-
dc.subject.keywordParkinson’s disease-
dc.contributor.alternativeNameKim, Yun Joong-
dc.contributor.affiliatedAuthor김윤중-
dc.citation.volume81-
dc.citation.startPage469-
dc.citation.endPage476-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROSCIENCE, Vol.81 : 469-476, 2020-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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