184 582

Cited 7 times in

Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk

DC Field Value Language
dc.contributor.author송유현-
dc.contributor.author박재민-
dc.contributor.author이지원-
dc.contributor.author권유진-
dc.date.accessioned2020-10-05T01:03:10Z-
dc.date.available2020-10-05T01:03:10Z-
dc.date.issued2020-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179734-
dc.description.abstractThe role of sodium in hypertension remains unresolved. Although genetic factors have a significant impact on high blood pressure, studies comparing genetic susceptibility between people with low and high sodium diets are lacking. We aimed to investigate the genetic variations related to hypertension according to sodium intake habits in a large Korean population-based study. Data for a total of 57,363 participants in the Korean Genome and Epidemiology Study Health Examination were analyzed. Sodium intake was measured by a semi-quantitative food frequency questionnaire. We classified participants according to sodium intake being less than or greater than 2 g/day. We used logistic regression to test single-marker variants for genetic association with a diagnosis of hypertension, adjusting for age, sex, body mass index, exercise, alcohol, smoking, potassium intake, principal components 1, and principal components 2. Significant associations were defined as p < 5 × 10-8. In participants whose sodium intake was greater than 2 g/day, chromosome 6 open reading frame 10 (C6orf10)-human leukocyte antigen (HLA)-DQB1 rs6913309, ring finger protein (RNF)213 rs112735431, glycosylphosphatidylinositol anchored molecule-like (GML)- cytochrome P450 family 11 subfamily B member 1(CYP11B1) rs3819496, myosin light chain 2 (MYL2)-cut like homeobox 2 (CUX2) rs12229654, and jagged1 (JAG1) rs1887320 were significantly associated with hypertension. In participants whose intake was less than 2 g/day, echinoderm microtubule-associated protein-like 6(EML6) rs67617923 was significantly associated with hypertension. Genetic susceptibility associated with hypertension differed according to sodium intake. Identifying gene variants that contribute to the dependence of hypertension on sodium intake status could make possible more individualized nutritional recommendations for preventing cardiovascular diseases.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI Publishing-
dc.relation.isPartOfNUTRIENTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIdentification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorYu-Jin Kwon-
dc.contributor.googleauthorJung Oh Kim-
dc.contributor.googleauthorJae-Min Park-
dc.contributor.googleauthorJa-Eun Choi-
dc.contributor.googleauthorDa-Hyun Park-
dc.contributor.googleauthorYouhyun Song-
dc.contributor.googleauthorSeong-Jin Kim-
dc.contributor.googleauthorJi-Won Lee-
dc.contributor.googleauthorKyung-Won Hong-
dc.identifier.doi10.3390/nu12092580-
dc.contributor.localIdA05650-
dc.contributor.localIdA04938-
dc.contributor.localIdA03203-
dc.contributor.localIdA04882-
dc.relation.journalcodeJ02396-
dc.identifier.eissn2072-6643-
dc.identifier.pmid32854392-
dc.subject.keywordhypertension-
dc.subject.keywordsingle-nucleotide polymorphism-
dc.subject.keywordsodium intake-
dc.contributor.alternativeNameSong, Youhyun-
dc.contributor.affiliatedAuthor송유현-
dc.contributor.affiliatedAuthor박재민-
dc.contributor.affiliatedAuthor이지원-
dc.contributor.affiliatedAuthor권유진-
dc.citation.volume12-
dc.citation.number9-
dc.citation.startPageE2580-
dc.identifier.bibliographicCitationNUTRIENTS, Vol.12(9) : E2580, 2020-09-
Appears in Collections:
6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.