Magnetic resonance imaging-based 3-dimensional fractal dimension and lacunarity analyses may predict the meningioma grade

Abstract

Objective: To assess whether 3-dimensional (3D) fractal dimension (FD) and lacunarity features from MRI can predict the meningioma grade.

Methods: This retrospective study included 131 patients with meningiomas (98 low-grade, 33 high-grade) who underwent preoperative MRI with post-contrast T1-weighted imaging. The 3D FD and lacunarity parameters from the enhancing portion of the tumor were extracted by box-counting algorithms. Inter-rater reliability was assessed with the intraclass correlation coefficient (ICC). Additionally, conventional imaging features such as location, heterogeneous enhancement, capsular enhancement, and necrosis were assessed. Independent clinical and imaging risk factors for meningioma grade were investigated using multivariable logistic regression. The discriminative value of the prediction model with and without fractal features was evaluated. The relationship of fractal parameters with the mitosis count and Ki-67 labeling index was also assessed.

Results: The inter-reader reliability was excellent, with ICCs of 0.99 for FD and 0.97 for lacunarity. High-grade meningiomas had higher FD (p < 0.001) and higher lacunarity (p = 0.007) than low-grade meningiomas. In the multivariable logistic regression, the diagnostic performance of the model with clinical and conventional imaging features increased with 3D fractal features for predicting the meningioma grade, with AUCs of 0.78 and 0.84, respectively. The 3D FD showed significant correlations with both mitosis count and Ki-67 labeling index, and lacunarity showed a significant correlation with the Ki-67 labeling index (all p values < 0.05).

Conclusion: The 3D FD and lacunarity are higher in high-grade meningiomas and fractal analysis may be a useful imaging biomarker for predicting the meningioma grade.

Key points: • Fractal dimension (FD) and lacunarity are the two parameters used in fractal analysis to describe the complexity of a subject and may aid in predicting meningioma grade. • High-grade meningiomas had a higher fractal dimension and higher lacunarity than low-grade meningiomas, suggesting higher complexity and higher rotational variance. • The discriminative value of the predictive model using clinical and conventional imaging features improved when combined with 3D fractal features for predicting the meningioma grade.