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Cidofovir Intralesional Injection for Recalcitrant Common Warts: A Comparison with Sodium Tetradecyl Sulfate Intralesional Injection

Authors
 Byung Ho Oh 
Citation
 ANNALS OF DERMATOLOGY, Vol.32(4) : 273-279, 2020-08 
Journal Title
 ANNALS OF DERMATOLOGY 
ISSN
 1013-9087 
Issue Date
2020-08
Keywords
Cidofovir ; Sodium tetradecyl sulfate ; Warts
Abstract
Background A novel treatment method is required for recalcitrant common warts. Objective This study aimed to compare the complete wart removal rate of cidofovir, a broad-spectrum antiviral agent, intralesional injection and sodium tetradecyl sulfate intralesional injection. Methods This retrospective study included 45 patients with recalcitrant common warts on the hands and/or feet, treated with cidofovir or sodium tetradecyl sulfate intralesional injection. Results The treatment results were evaluated in three groups as follows: (1) failure - recalcitrant common warts remaining despite three or more injections, (2) success - free from warts for more than 6 months after the injection, and (3) recurrence. The cidofovir group (n=22) showed significantly higher treatment success rates than the sodium tetradecyl sulfate group (n=23) (90.91% vs. 26.09%, p<0.001). Two immunosuppressed patients in the cidofovir group had recurrent lesions after 2 months of being declared free from warts. Considering adverse effects, two patients in the cidofovir group complained of bulla formation with severe pain requiring narcotic painkillers. Conclusion Although this study has the limitations of a small sample size and retrospective design, patients with recalcitrant common warts showed a dramatic response to the treatment with cidofovir intralesional injection, with minimal complications.
DOI
10.5021/ad.2020.32.4.273
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byung Ho(오병호) ORCID logo https://orcid.org/0000-0001-9575-5665
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179675
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