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Association of maxillary dental developmental abnormality with precocious puberty: a case-control study

 Yesel Kim  ;  Nam-Ki Lee  ;  Jae Hyun Kim  ;  Jeong-Kui Ku  ;  Bu-Kyu Lee  ;  Hoi-In Jung  ;  Sun-Kyu Choi 
 Maxillofacial Plastic and Reconstructive Surgery, Vol.42(1) : 30, 2020-08 
Journal Title
Maxillofacial Plastic and Reconstructive Surgery
Issue Date
Dental developmental abnormality ; Gonadotropin-releasing hormone ; Mesiodens ; Precocious puberty ; Supernumerary tooth
Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs).

Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively.

Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP.

Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.
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2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Hoi In(정회인) ORCID logo https://orcid.org/0000-0002-1978-6926
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