0 7

Cited 0 times in

Depressive symptoms, its sub-factors, and augmentation index: the modifying effects according to inflammatory markers

Authors
 Ye Jin Jeon  ;  So Mi Jemma Cho  ;  Yu Jin Lee  ;  Hyeon Chang Kim  ;  Sun Jae Jung 
Citation
 JOURNAL OF AFFECTIVE DISORDERS, Vol.272 : 380-387, 2020-07 
Journal Title
 JOURNAL OF AFFECTIVE DISORDERS 
ISSN
 0165-0327 
Issue Date
2020-07
Keywords
Augmentation index ; Depressive symptoms ; Inflammation
Abstract
Background This study aimed to investigate the association between depression and the augmentation index (AIx), and to further investigate whether there is a difference in this association according to the patients' inflammatory status. Methods This study included 458 men and 815 women (mean age: 49.35 years), a community-dwelling and middle-aged Korean population. The Korean version of the Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms. Arterial stiffness was evaluated via an AIx normalized to 75 beats/min. We confirmed two factors from BDI-II after conducting a factor analysis. Multiple regression models were used after adjusting for socio-demographic factors, lifestyle factors, systolic blood pressure, diabetes history, and body mass index. We further stratified the data according to inflammatory biomarkers with cutoffs of the 75th percentile. Results There was a significant positive association between the BDI-II score and arterial stiffness (ß= 0.09, p-value=0.037). In women, the somatic-affective factor showed a stronger positive association (ß= 0.20, p-value=0.018) with arterial stiffness than the cognitive factor (ß= 0.12, p-value=0.148). There was no significant association in men (ß= -0.01, p-value=0.943). In subgroup analyses, women showed significant positive associations between the somatic affective factor of depressive symptoms on and arterial stiffness according to both inflammatory markers (IL-6: ß= 0.17, p-value=0.039; hs-CRP: ß= 0.17, p-value=0.094) Limitations The design of the cross-sectional study limits causal interpretation. Conclusion Depression and its somatic-affective factor were positively associated with arterial stiffness in women. Inflammatory status may be involved in modifying the association between depressive symptoms, its sub-factors, and AIx.
Full Text
https://www.sciencedirect.com/science/article/pii/S0165032719331787
DOI
10.1016/j.jad.2020.03.174
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Jung, Sun Jae(정선재) ORCID logo https://orcid.org/0000-0002-5194-7339
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179583
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links