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Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study

Authors
 Sung-Wook Yoon  ;  Myong-Ji Kim  ;  Kyeong-Won Paeng  ;  Kyeong Ae Yu  ;  Chong-Kil Lee  ;  Young Woo Song  ;  Jae-Kook Cha  ;  Mariano Sanz  ;  Ui-Won Jung 
Citation
 PHARMACEUTICS, Vol.12(7) : 668, 2020-07 
Journal Title
 PHARMACEUTICS 
Issue Date
2020-07
Keywords
chitosan-alginate microspheres ; drug sustainability ; local minocycline agent ; peri-implant mucositis ; pharmacodynamic
Abstract
Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes.
Files in This Item:
T202002891.pdf Download
DOI
10.3390/pharmaceutics12070668
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Song, Young Woo(송영우) ORCID logo https://orcid.org/0000-0003-1835-5646
Yoon, Sung-Wook(윤성욱)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179538
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