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Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Authors
 Jeong Seok Lee  ;  Seongwan Park  ;  Hye Won Jeong  ;  Jin Young Ahn  ;  Seong Jin Choi  ;  Hoyoung Lee  ;  Baekgyu Choi  ;  Su Kyung Nam  ;  Moa Sa  ;  Ji-Soo Kwon  ;  Su Jin Jeong  ;  Heung Kyu Lee  ;  Sung Ho Park  ;  Su-Hyung Park  ;  Jun Yong Choi  ;  Sung-Han Kim  ;  Inkyung Jung  ;  Eui-Cheol Shin 
Citation
 SCIENCE IMMUNOLOGY, Vol.5(49) : eabd1554, 2020-07 
Journal Title
 SCIENCE IMMUNOLOGY 
Issue Date
2020-07
MeSH
Adult ; Aged ; Aged, 80 and over ; Betacoronavirus / genetics* ; Betacoronavirus / immunology* ; CD8-Positive T-Lymphocytes / immunology ; Cells, Cultured ; Coronavirus Infections / blood ; Coronavirus Infections / immunology* ; Coronavirus Infections / virology ; Female ; Healthy Volunteers ; Humans ; Immunophenotyping* ; Inflammation / immunology ; Influenza A virus / immunology* ; Influenza, Human / blood ; Influenza, Human / immunology* ; Influenza, Human / virology ; Interferon Type I / metabolism* ; Interleukin-1beta / metabolism ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral / blood ; Pneumonia, Viral / immunology* ; Pneumonia, Viral / virology ; RNA-Seq ; Severity of Illness Index* ; Single-Cell Analysis ; Transcriptome ; Tumor Necrosis Factor-alpha / metabolism
Abstract
Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1β-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1β-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
Files in This Item:
T202002939.pdf Download
DOI
10.1126/sciimmunol.abd1554
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jin Young(안진영) ORCID logo https://orcid.org/0000-0002-3740-2826
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179475
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