16 21

Cited 0 times in

Shared functional neural substrates in Parkinson's disease and drug-induced parkinsonism: association with dopaminergic depletion

DC FieldValueLanguage
dc.contributor.author이승구-
dc.date.accessioned2020-09-29T01:18:36Z-
dc.date.available2020-09-29T01:18:36Z-
dc.date.issued2020-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179468-
dc.description.abstractWhile drug-induced parkinsonism (DIP) is mainly caused by blockage of the dopaminergic pathway, multiple neurotransmitter systems besides the dopaminergic system are involved in Parkinson's disease (PD). Therefore, alterations found in both DIP and PD might be manifestations of dopaminergic dysfunction. To prove this hypothesis, we aimed to define the areas commonly involved in DIP and PD and determine whether the overlapping areas were associated with the dopaminergic system. 68 PD patients, 69 DIP patients and 70 age-and sex-matched controls underwent resting-state functional MRI (rsfMRI). Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF) and fractional ALFF were calculated and compared. Afterwards, we compared mean rsfMRI values extracted from the overlapping areas with uptake quantitatively measured on dopamine transporter (DAT) images and neuropsychological test results. Compared to the controls, both PD and DIP patients revealed altered rsfMRI values in the right insular cortex, right temporo-occipital cortex, and cerebellum. Among them, decreased ALFF in the right insular cortex and decreased ReHo in the right occipital cortex were correlated with decreased DAT uptake in the caudate as well as executive, visuospatial, and language function. Increased ReHo in the cerebellum was also correlated with decrease DAT uptake in the posterior and ventral anterior putamen, but not with cognitive function. In conclusion, the insular cortex, occipital cortex, and cerebellum were commonly affected in both PD and DIP patients and might be associated with altered dopaminergic modulation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleShared functional neural substrates in Parkinson's disease and drug-induced parkinsonism: association with dopaminergic depletion-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorSe Won Oh-
dc.contributor.googleauthorNa-Young Shin-
dc.contributor.googleauthorUicheul Yoon-
dc.contributor.googleauthorIntae Sin-
dc.contributor.googleauthorSeung-Koo Lee-
dc.identifier.doi10.1038/s41598-020-68514-0-
dc.contributor.localIdA02912-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32669608-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.affiliatedAuthor이승구-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage11617-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 11617, 2020-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.