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Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis

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dc.contributor.author고홍-
dc.contributor.author윤혜성-
dc.contributor.author신현주-
dc.contributor.author이미정-
dc.contributor.author한석주-
dc.date.accessioned2020-09-29T00:42:50Z-
dc.date.available2020-09-29T00:42:50Z-
dc.date.issued2020-06-
dc.identifier.issn1007-9327-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179376-
dc.description.abstractBackground: Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver transplantation. Therefore, non-invasive evaluation of hepatic fibrosis is important in infants with cholestasis. Aim: To investigate the usefulness of periportal thickening (PT) measured on liver magnetic resonance imaging (MRI) for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia (BA). Methods: This retrospective study included infants less than 6 mo who underwent liver MRI and biopsy for the evaluation of infantile cholestasis. PT and spleen size were measured on MRI. Serologic assessment was based on aspartate transaminase to platelet ratio index (APRI). The grade of histopathologic fibrosis was assessed by the METAVIR grading system. Correlation and diagnostic performance of PT, normalized spleen size ratio (SR, using the upper normal size limit), and APRI for diagnosing hepatic fibrosis were obtained by receiver-operating characteristic (ROC) curve analysis. Results: A total of 155 patients were included, 110 of which were diagnosed with BA. Mean age at the time of MRI was 57.6 ± 34.4 d. There were positive correlations between fibrosis grade and PT and SR, even after adjusting age (all, P < 0.001). For the diagnosis of significant fibrosis (METAVIR grade F2-F4), the area under the ROC curve was 0.899 (95%CI: 0.840-0.941) for PT (cutoff, 4.2 mm), which was higher than 0.741 (95%CI: 0.664-0.808) for SR and 0.712 (95%CI: 0.634-0.782) for APRI (both, P < 0.001). For the diagnosis of cirrhosis (F4), the area under the ROC curve was the highest with SR as 0.790 (95%CI: 0.718-0.852). Conclusion: Liver MRI findings of PT and SR are useful to assess clinically significant hepatic fibrosis (F2 and higher) in infants with cholestasis including BA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBaishideng Publishing Group-
dc.relation.isPartOfWORLD JOURNAL OF GASTROENTEROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePeriportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorMyung Hwan Lee-
dc.contributor.googleauthorHyun Joo Shin-
dc.contributor.googleauthorHaesung Yoon-
dc.contributor.googleauthorSeok Joo Han-
dc.contributor.googleauthorHong Koh-
dc.contributor.googleauthorMi-Jung Lee-
dc.identifier.doi10.3748/wjg.v26.i21.2821-
dc.contributor.localIdA00156-
dc.contributor.localIdA04989-
dc.contributor.localIdA02178-
dc.contributor.localIdA02774-
dc.contributor.localIdA04288-
dc.relation.journalcodeJ02795-
dc.identifier.eissn2219-2840-
dc.identifier.pmid32550757-
dc.subject.keywordBiliary atresia-
dc.subject.keywordCholestasis-
dc.subject.keywordFibrosis-
dc.subject.keywordInfants-
dc.subject.keywordLiver-
dc.subject.keywordMagnetic resonance imaging-
dc.contributor.alternativeNameKoh, Hong-
dc.contributor.affiliatedAuthor고홍-
dc.contributor.affiliatedAuthor윤혜성-
dc.contributor.affiliatedAuthor신현주-
dc.contributor.affiliatedAuthor이미정-
dc.contributor.affiliatedAuthor한석주-
dc.citation.volume26-
dc.citation.number21-
dc.citation.startPage2821-
dc.citation.endPage2830-
dc.identifier.bibliographicCitationWORLD JOURNAL OF GASTROENTEROLOGY, Vol.26(21) : 2821-2830, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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