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Cited 3 times in

Phase I Radiation Dose-Escalation Study to Investigate the Dose-Limiting Toxicity of Concurrent Intra-Arterial Chemotherapy for Unresectable Hepatocellular Carcinoma

DC Field Value Language
dc.contributor.author이관식-
dc.contributor.author이정일-
dc.contributor.author이현웅-
dc.contributor.author김자경-
dc.contributor.author이익재-
dc.contributor.author김준원-
dc.contributor.author조연아-
dc.contributor.author이광훈-
dc.contributor.author주승문-
dc.contributor.author임진홍-
dc.date.accessioned2020-09-28T12:14:35Z-
dc.date.available2020-09-28T12:14:35Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179357-
dc.description.abstractConcurrent intra-arterial chemotherapy and radiotherapy (iA-CCRT) can increase the response rate in hepatocellular carcinoma (HCC), but may cause a higher toxicity. We conducted this Phase I study to investigate the dose-limiting toxicity of iA-CCRT for HCC. In total, 52.5 Gy in 25 fractions was prescribed as planning target volume (PTV) 1 at dose level 1. The dose escalation was 0.2 Gy per fraction and up to 2.5 Gy, with 62.5 Gy at level 3. Concurrent intra-arterial 5-fluorouracil was administered during the first and fifth weeks of radiotherapy (RT). Toxicities were graded using the Common Toxicity Criteria for Adverse Events, version 4.0. Results: Seventeen patients with HCC were analyzed: four at dose level 1, 6 at level 2, and 7 at level 3. The mean irradiated dose administered to the uninvolved liver at each dose level was 21.3, 21.6, and 18.2 Gy, respectively. There was no grade ≥3 gastrointestinal toxicity; two patients experienced grade 3 hyperbilirubinemia. All patients had Child-Pugh class A disease, but 3 patients developed class B disease after iA-CCRT. During a median follow-up of 13 months, the median progression-free survival (PFS) and overall survival (OS) were 10 and 22 months, respectively. Patients treated at dose level 3 showed improved PFS and OS. Conclusions: Radiation dose escalation of iA-CCRT did not cause any significant toxicities in patients with advanced HCC. Further large-scale studies with long-term follow-up are needed to determine the efficacy and feasibility of higher doses of iA-CCRT.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePhase I Radiation Dose-Escalation Study to Investigate the Dose-Limiting Toxicity of Concurrent Intra-Arterial Chemotherapy for Unresectable Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYeona Cho-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorJung Il Lee-
dc.contributor.googleauthorHyun Woong Lee-
dc.contributor.googleauthorKwang-Hun Lee-
dc.contributor.googleauthorSeung-Moon Joo-
dc.contributor.googleauthorJin Hong Lim-
dc.contributor.googleauthorIk Jae Lee-
dc.identifier.doi10.3390/cancers12061612-
dc.contributor.localIdA02666-
dc.contributor.localIdA03122-
dc.contributor.localIdA03292-
dc.contributor.localIdA00852-
dc.contributor.localIdA03055-
dc.contributor.localIdA00958-
dc.contributor.localIdA04680-
dc.contributor.localIdA02676-
dc.contributor.localIdA05043-
dc.contributor.localIdA03411-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid32570869-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordchemoradiotherapy-
dc.subject.keywordradiotherapy-
dc.subject.keywordtoxicity-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.affiliatedAuthor이관식-
dc.contributor.affiliatedAuthor이정일-
dc.contributor.affiliatedAuthor이현웅-
dc.contributor.affiliatedAuthor김자경-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor김준원-
dc.contributor.affiliatedAuthor조연아-
dc.contributor.affiliatedAuthor이광훈-
dc.contributor.affiliatedAuthor주승문-
dc.contributor.affiliatedAuthor임진홍-
dc.citation.volume12-
dc.citation.number6-
dc.citation.startPage1612-
dc.identifier.bibliographicCitationCANCERS, Vol.12(6) : 1612, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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