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Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies

Authors
 Hee Jin  ;  Youngjo Yoo  ;  Younghwa Kim  ;  Yeijin Kim  ;  Jaeho Cho  ;  Yun-Sil Lee 
Citation
 CANCERS, Vol.12(6) : 1561, 2020-06 
Journal Title
 CANCERS 
Issue Date
2020-06
Keywords
animal models ; antifibrotic ; lung fibrosis ; radiation ; therapeutic targets
Abstract
Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation, and differentiation of fibroblasts and, finally, results in excessive extracellular matrix deposition. Currently, there are no approved treatment options for patients with radiation-induced pulmonary fibrosis (RIPF) partly due to the absence of effective targets. Current research advances include the development of small animal models reflecting modern radiotherapy, an understanding of the molecular basis of RIPF, and the identification of candidate drugs for prevention and treatment. Insights provided by this research have resulted in increased interest in disease progression and prognosis, the development of novel anti-fibrotic agents, and a more targeted approach to the treatment of RIPF.
Files in This Item:
T202002195.pdf Download
DOI
10.3390/cancers12061561
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179356
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