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Cardiotoxicity evaluation using magnetic resonance imaging in breast Cancer patients (CareBest): study protocol for a prospective trial

DC FieldValueLanguage
dc.contributor.author김건민-
dc.contributor.author이혜정-
dc.contributor.author김영진-
dc.contributor.author김민정-
dc.contributor.author허진-
dc.contributor.author홍유진-
dc.contributor.author최병욱-
dc.date.accessioned2020-09-28T12:00:44Z-
dc.date.available2020-09-28T12:00:44Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179315-
dc.description.abstractBackground: Cardiovascular disease is second only to cancer recurrence as a determinant of lifespan in cancer survivors, and cancer therapy-related cardiac dysfunction is a clinically important risk factor. We aim to investigate the use of cardiac magnetic resonance imaging (MRI) to evaluate early tissue changes and perform functional assessment of chemo- and radiation-induced cardiotoxicity and to identify MRI prognostic indicators of cardiotoxicity in breast cancer patients. Methods: A 3-min cardiac imaging protocol will be added to the breast MRI examination to diagnose cardiotoxicity in breast cancer patients. Standardized MRI-based evaluation of breast cancer and the left ventricular myocardium will be performed at baseline and at 3, 6, and 12 months and 2 years or more after cancer treatment. We will analyze both ventricular volume and ejection fraction (EF), strain of left ventricle (LV), native T1, extracellular volume fraction (ECV), and T2 values acquired in the mid LV. Discussion: The primary result of this study will be the comparison of the prognostic value of MRI parameters (native T1, ECV, both ventricular systolic function and LV strain) for cardiotoxicity. The endpoint is defined as the occurrence of a major adverse cardiac event (MACE). The secondary outcome will be an assessment of the temporal relationships between contractile dysfunction and microstructural injury over 4 years using MRI. This study will assess the usefulness of quantitative MRI to diagnose cardiotoxicity and will clarify the temporal relationships between contractile dysfunction and microstructural injury of the LV myocardium using MRI during breast cancer treatment. Trial registration: The protocol was registered at clinicaltrials.gov (Clinical trial no. NCT03301389) on October 4, 2017.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC CARDIOVASCULAR DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCardiotoxicity evaluation using magnetic resonance imaging in breast Cancer patients (CareBest): study protocol for a prospective trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoo Jin Hong-
dc.contributor.googleauthorGun Min Kim-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorPan Ki Kim-
dc.contributor.googleauthorSu An Lee-
dc.contributor.googleauthorEunkyung An-
dc.contributor.googleauthorJi Yeon Lee-
dc.contributor.googleauthorHye-Jeong Lee-
dc.contributor.googleauthorJin Hur-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorByoung Wook Choi-
dc.identifier.doi10.1186/s12872-020-01497-y-
dc.contributor.localIdA00287-
dc.contributor.localIdA03320-
dc.contributor.localIdA03320-
dc.contributor.localIdA00727-
dc.contributor.localIdA00727-
dc.contributor.localIdA00473-
dc.contributor.localIdA00473-
dc.contributor.localIdA04370-
dc.contributor.localIdA04370-
dc.contributor.localIdA04422-
dc.contributor.localIdA04422-
dc.contributor.localIdA04059-
dc.contributor.localIdA04059-
dc.relation.journalcodeJ00352-
dc.identifier.eissn1471-2261-
dc.identifier.pmid32493217-
dc.subject.keywordCardiotoxicity-
dc.subject.keywordExtracellular volume fraction-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordNative T1-
dc.subject.keywordT1 mapping-
dc.contributor.alternativeNameKim, Gun Min-
dc.contributor.affiliatedAuthor김건민-
dc.contributor.affiliatedAuthor이혜정-
dc.contributor.affiliatedAuthor이혜정-
dc.contributor.affiliatedAuthor김영진-
dc.contributor.affiliatedAuthor김영진-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor허진-
dc.contributor.affiliatedAuthor허진-
dc.contributor.affiliatedAuthor홍유진-
dc.contributor.affiliatedAuthor홍유진-
dc.contributor.affiliatedAuthor최병욱-
dc.contributor.affiliatedAuthor최병욱-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPage264-
dc.identifier.bibliographicCitationBMC CARDIOVASCULAR DISORDERS, Vol.20(1) : 264, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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