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Patterns of olfactory functional networks in Parkinson's disease dementia and Alzheimer's dementia

Authors
 Yang Hyun Lee  ;  Yunjin Bak  ;  Chang-Hyun Park  ;  Seok Jong Chung  ;  Han Soo Yoo  ;  Kyoungwon Baik  ;  Jin Ho Jung  ;  Young H Sohn  ;  Na-Young Shin  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.89 : 63-70, 2020-05 
Journal Title
 NEUROBIOLOGY OF AGING 
ISSN
 0197-4580 
Issue Date
2020-05
Keywords
Alzheimer's dementia ; Functional magnetic resonance imaging ; Functional network ; Olfaction ; Parkinson's disease dementia
Abstract
Hyposmia is common in Alzheimer's dementia (AD) and Parkinson's disease dementia (PDD). We evaluated the pattern of olfactory functional connectivity (FC) in AD and PDD to uncover neural correlates that are related to olfactory dysfunction. This study enrolled 57 patients with AD and PDD and 25 control subjects. Using a seed-based approach, we compared the resting-state network from the seed-region-of-interest in the olfactory bulb, olfactory tract, piriform cortex, and orbitofrontal cortex (OFC) between groups. The PDD group showed lower FC with striatal-thalamic-frontal regions from the olfactory bulb than the AD group. The PDD group showed lower FC from left OFC with striatal-frontal regions and lower FC from right OFC with left fronto-temporal areas than the AD group. In a correlation analysis, the FC from left OFC with right insula that differed between the PDD and control groups was positively correlated with olfactory function. The present study demonstrated that this distinct olfactory functional network pattern may represent different neural mechanisms for olfactory dysfunction in AD and PDD.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458019304506
DOI
10.1016/j.neurobiolaging.2019.12.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179272
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