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Neural Basis of Ambivalence towards Ideal Self-Image in Schizophrenia

Authors
 Byung-Hoon Kim  ;  Yu-Bin Shin  ;  Sunghyon Kyeong  ;  Seon-Koo Lee  ;  Jae-Jin Kim 
Citation
 PSYCHIATRY INVESTIGATION, Vol.17(5) : 452-459, 2020-05 
Journal Title
 PSYCHIATRY INVESTIGATION 
ISSN
 1738-3684 
Issue Date
2020-05
Keywords
Ambivalence ; Functional magnetic resonance imaging ; Schizophrenia ; Self-image
Abstract
Objective: Little has been explored about a reflection towards self-image in schizophrenia, though it can be related to heterogeneous symptoms of the illness. We identified the neural basis of ambivalence towards ideal self-image in patients with schizophrenia. Methods: 20 patients with schizophrenia and 20 healthy controls underwent functional MRI while the self-image reflection tasks of determining whether to agree with sentences describing their actual or ideal self-image that contained one of the adjective pairs with opposite valence. The interaction between the group and ideal ambivalence score was examined, and group differences in functional connectivity related to ambivalence towards ideal self-image were further studied. Results: The interaction of group-by-ideal ambivalence score was shown in the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex, where activities were positively correlated with the level of ideal self-image ambivalence in patients, but not in controls. Task-related decrease in functional connectivity was shown between the orbitofrontal cortex and cerebellum in patients. Conclusion: The process of reflecting on ambivalent ideal self-image in schizophrenia may be related to aberrant prefrontal activity and connectivity. Abnormality in the prefrontal regions that take part in cognitive conflict monitoring and value judgment may underlie the pathophysiology of increased ambivalence towards ideal self-image.
Files in This Item:
T202003120.pdf Download
DOI
10.30773/pi.2019.0320
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179207
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