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Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study

Authors
 Se Hwa Kim  ;  Yumie Rhee  ;  Yoo Mee Kim  ;  Young Jun Won  ;  Junghyun Noh  ;  Hyemi Moon  ;  Juneyoung Lee  ;  Sin Gon Kim 
Citation
 PLOS ONE, Vol.15(5) : e0232842, 2020-05 
Journal Title
 PLOS ONE 
Issue Date
2020-05
MeSH
Adult ; Autoimmune Diseases / epidemiology ; Bipolar Disorder / epidemiology ; Bipolar Disorder / etiology ; Cardiovascular Diseases / epidemiology ; Cardiovascular Diseases / etiology ; Case-Control Studies ; Cataract / epidemiology ; Cataract / etiology ; Comorbidity ; Depressive Disorder / epidemiology ; Depressive Disorder / etiology ; Female ; Fractures, Spontaneous / epidemiology ; Fractures, Spontaneous / etiology ; Humans ; Hypoparathyroidism / complications ; Hypoparathyroidism / epidemiology* ; Male ; Metabolic Syndrome / epidemiology ; Middle Aged ; Prevalence ; Propensity Score ; Republic of Korea / epidemiology ; Seizures / epidemiology ; Seizures / etiology ; Spinal Fractures / epidemiology ; Spinal Fractures / etiology ; Urinary Calculi / epidemiology ; Urinary Calculi / etiology ; Young Adult
Abstract
Objective: The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods: We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results: The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls. Conclusions: The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.
Files in This Item:
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DOI
10.1371/journal.pone.0232842
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179195
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