Cited 28 times in
Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.date.accessioned | 2020-09-28T11:13:56Z | - |
dc.date.available | 2020-09-28T11:13:56Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179195 | - |
dc.description.abstract | Objective: The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods: We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results: The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls. Conclusions: The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Autoimmune Diseases / epidemiology | - |
dc.subject.MESH | Bipolar Disorder / epidemiology | - |
dc.subject.MESH | Bipolar Disorder / etiology | - |
dc.subject.MESH | Cardiovascular Diseases / epidemiology | - |
dc.subject.MESH | Cardiovascular Diseases / etiology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cataract / epidemiology | - |
dc.subject.MESH | Cataract / etiology | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Depressive Disorder / epidemiology | - |
dc.subject.MESH | Depressive Disorder / etiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fractures, Spontaneous / epidemiology | - |
dc.subject.MESH | Fractures, Spontaneous / etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoparathyroidism / complications | - |
dc.subject.MESH | Hypoparathyroidism / epidemiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome / epidemiology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Seizures / epidemiology | - |
dc.subject.MESH | Seizures / etiology | - |
dc.subject.MESH | Spinal Fractures / epidemiology | - |
dc.subject.MESH | Spinal Fractures / etiology | - |
dc.subject.MESH | Urinary Calculi / epidemiology | - |
dc.subject.MESH | Urinary Calculi / etiology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Se Hwa Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Yoo Mee Kim | - |
dc.contributor.googleauthor | Young Jun Won | - |
dc.contributor.googleauthor | Junghyun Noh | - |
dc.contributor.googleauthor | Hyemi Moon | - |
dc.contributor.googleauthor | Juneyoung Lee | - |
dc.contributor.googleauthor | Sin Gon Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0232842 | - |
dc.contributor.localId | A03012 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32384131 | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e0232842 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(5) : e0232842, 2020-05 | - |
dc.identifier.rimsid | 67366 | - |
dc.type.rims | ART | - |
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