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Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer
DC Field | Value | Language |
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dc.contributor.author | 김태일 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 허혁 | - |
dc.contributor.author | 조민수 | - |
dc.date.accessioned | 2020-09-28T02:36:24Z | - |
dc.date.available | 2020-09-28T02:36:24Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1000-9604 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179109 | - |
dc.description.abstract | Objective: The aim of this study is to develop a nomogram for prediction of pathologic complete remission (pCR) after preoperative chemoradiotherapy (CRT) for rectal cancer. Methods: mRNA expression levels of seven molecular markers [p53, p21, Ki-67, vascular endothelial growth factor (VEGF), CD133, CD24, CD44] were measured by reverse transcriptase polymerase chain reaction (RT-PCR) in 120 rectal cancers. Endoscopic findings of clinical complete remission (cCR) and biologic variables were used to construct nomogram in the training group (n=80), which was validated in the validation group (n=40). Results: mRNA expression levels of four markers (p53, p21, Ki67, CD133) correlated with pCR (24/80, 30.0%) in the training group. Low expression of p53 and/or high expression of p21, Ki67 and CD133 showed greater pCR rate. pCR was shown in 18 (69.2%) of 26 cases showing endoscopic cCR in the training group. Higher pCR rate was demonstrated in lower tumor location than middle tumor (19/49, 38.8% vs. 5/31, 16.1%). A nomogram for prediction of pCR was developed from the multivariate prediction model using these six variables, which showed good discrimination ability in the training group [area under the curve (AUC)=0.945] and validation group (AUC=0.922). The calibration plot showed good agreement between actual and predicted pCR in both patient groups. Conclusions: Nomogram for assessment of pCR can be useful for making treatment decisions after CRT according to predicted responses. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Beijing Institute for Cancer Research | - |
dc.relation.isPartOf | CHINESE JOURNAL OF CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.identifier.doi | 10.21147/j.issn.1000-9604.2020.02.10 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A02262 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A04373 | - |
dc.contributor.localId | A03817 | - |
dc.relation.journalcode | J00526 | - |
dc.identifier.eissn | 1993-0631 | - |
dc.identifier.pmid | 32410800 | - |
dc.subject.keyword | Rectal cancer | - |
dc.subject.keyword | chemoradiotherapy | - |
dc.subject.keyword | endoscopy | - |
dc.subject.keyword | molecular marker | - |
dc.subject.keyword | nomogram | - |
dc.subject.keyword | treatment response | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | 김태일 | - |
dc.contributor.affiliatedAuthor | 안중배 | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 임준석 | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.contributor.affiliatedAuthor | 조민수 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 228 | - |
dc.citation.endPage | 241 | - |
dc.identifier.bibliographicCitation | CHINESE JOURNAL OF CANCER RESEARCH, Vol.32(2) : 228-241, 2020-04 | - |
dc.identifier.rimsid | 67492 | - |
dc.type.rims | ART | - |
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