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Distinctive Nanogels as high-efficiency Transdermal Carriers fot Skin Wound healing

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dc.contributor.author손혜영-
dc.contributor.author허용민-
dc.date.accessioned2020-09-28T02:32:14Z-
dc.date.available2020-09-28T02:32:14Z-
dc.date.issued2020-03-
dc.identifier.issn1550-7033-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179089-
dc.description.abstractWe propose that nanogels (HLGs) prepared by simply blending an epidermal growth factor (EGF)-loaded hyaluronan (HA)-based nanoformulation and poloxamers can be efficient transdermal drug carriers. In particular, due to the thermogelling behavior of poloxamer, when the HLGs, which are liquid at room temperature, are applied to the skin's surface, they form a gel at skin temperature. First, lipid-based nanoformulations (EGF-LNs) were fabricated by the lipid thin film method and then chemically conjugated with HA on the surface of the films to prepare EGF-loaded HA-based nanoformulations (EGF-HLNs). Both EGF-LNs and EGF-HLNs exhibited a uniform size and spherical lamellar structure. The EGF-HLN was added to a poloxamer solution to form EGF-HLG, which is a liquid at room temperature and a gel at skin temperature. HLGs have been shown to be able to deliver and permeate EGF well into the skin using both in vitro and in vivo systems, thus serving as an effective transdermal delivery system. In addition, it has been confirmed that this system could be a possible implantable drug carrier. Therefore, HLGs, which are uncomplicated and easily prepared, are expected to be easily used not only in the pharmaceutical field but also in the cosmetic field.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Scientific Publishers-
dc.relation.isPartOfJOURNAL OF BIOMEDICAL NANOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdministration, Cutaneous-
dc.subject.MESHDrug Carriers-
dc.subject.MESHEpidermal Growth Factor-
dc.subject.MESHNanogels*-
dc.subject.MESHSkin-
dc.subject.MESHWound Healing*-
dc.titleDistinctive Nanogels as high-efficiency Transdermal Carriers fot Skin Wound healing-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorSeong Uk Son-
dc.contributor.googleauthorSoojin Jang-
dc.contributor.googleauthorYuna Choi-
dc.contributor.googleauthorMirae Park-
dc.contributor.googleauthorHye Young Son-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSoo-Jin Yeom-
dc.contributor.googleauthorMoon Sun Ham-
dc.contributor.googleauthorDo Kyung Lee-
dc.contributor.googleauthorHan-Na Kim-
dc.contributor.googleauthorYeung-Bae Jin-
dc.contributor.googleauthorTaejoon Kang-
dc.contributor.googleauthorJuyeon Jung-
dc.contributor.googleauthorEun-Kyung Lim-
dc.identifier.doi10.1166/jbn.2020.2893-
dc.contributor.localIdA04589-
dc.contributor.localIdA04359-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ01268-
dc.identifier.eissn1550-7041-
dc.identifier.pmid32493541-
dc.identifier.urlhttps://www.ingentaconnect.com/content/asp/jbn/2020/00000016/00000003/art00003;jsessionid=jd52x9ag3hmk.x-ic-live-03-
dc.contributor.alternativeNameSon, Hye Yeong-
dc.contributor.affiliatedAuthor손혜영-
dc.contributor.affiliatedAuthor허용민-
dc.contributor.affiliatedAuthor허용민-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage304-
dc.citation.endPage314-
dc.identifier.bibliographicCitationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.16(3) : 304-314, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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