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Review on long-term non-renal complications of childhood nephrotic syndrome

Authors
 Jiwon M Lee  ;  Andreas Kronbichler  ;  Jae Il Shin  ;  Jun Oh 
Citation
 ACTA PAEDIATRICA, Vol.109(3) : 460-470, 2020-03 
Journal Title
 ACTA PAEDIATRICA 
ISSN
 0803-5253 
Issue Date
2020-03
Keywords
long-term ; morbidity ; nephrotic syndrome ; non-renal complications ; prognosis ; quality of life
Abstract
Background: Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long-term renal prognosis of childhood-onset idiopathic NS. However, the nonrenal outcomes have not been studied as much. Aim: We aimed to discuss the long-term non-renal outcomes of childhood NS, highlighting studies with a follow-up period of more than 10 years. Results: We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non-renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non-renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies. Conclusion: This review discusses and summarises the non-renal outcomes of idiopathic childhood NS.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.15035
DOI
10.1111/apa.15035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179087
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