0 7

Cited 0 times in

Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD

 Changhwan Kim  ;  Yousang Ko  ;  Ji Ye Jung  ;  Jae Seung Lee  ;  Chin Kook Rhee  ;  Jin Hwa Lee  ;  Ji-Hyun Lee  ;  Ji-Yong Moon  ;  Seong Yong Lim  ;  Kwang Ha Yoo  ;  Joon Beom Seo  ;  Yeon-Mok Oh  ;  Sang-Do Lee  ;  Yong Bum Park 
 RESPIRATORY MEDICINE, Vol.163 : 105890, 2020-03 
Journal Title
Issue Date
Chronic obstructive pulmonary disease ; Emphysema ; Vitamin D
Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (≥20 ng/ml), mild deficiency (15-20 ng/ml), moderate deficiency (10-15 ng/ml), and severe deficiency (<10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.