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Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD
DC Field | Value | Language |
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dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2020-09-28T02:30:42Z | - |
dc.date.available | 2020-09-28T02:30:42Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179078 | - |
dc.description.abstract | Background: Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of vitamin D deficiency. Vitamin D levels also correlate with lung function in patients with COPD. However, there are few reports on vitamin D deficiency and emphysema severity in COPD. This study aimed to investigate the effects of plasma 25-hydroxyvitamin D (25-OHD) level on emphysema severity in male COPD patients. Methods: A total of 151 male subjects were selected from the Korean Obstructive Lung Disease (KOLD) cohort. Subjects were subdivided into four subgroups according to their baseline plasma 25-OHD level: sufficiency (≥20 ng/ml), mild deficiency (15-20 ng/ml), moderate deficiency (10-15 ng/ml), and severe deficiency (<10 ng/ml). Results: Baseline computed tomography (CT) emphysema indices revealed significant differences among the subgroups (p = 0.034). A statistically significant difference was also observed among the subgroups regarding change in the CT emphysema index over 3 years (p = 0.047). The annual increase in emphysema index was more prominent in the severe deficiency group (1.34% per year) than in the other groups (0.41% per year) (p = 0.003). Conclusions: This study demonstrates that CT emphysema indices were different among the four subgroups and supports that severe vitamin D deficiency is associated with rapid progression of emphysema in male patients with COPD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W.B. Saunders | - |
dc.relation.isPartOf | RESPIRATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Severe vitamin D deficiency is associated with emphysema progression in male patients with COPD | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Changhwan Kim | - |
dc.contributor.googleauthor | Yousang Ko | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Chin Kook Rhee | - |
dc.contributor.googleauthor | Jin Hwa Lee | - |
dc.contributor.googleauthor | Ji-Hyun Lee | - |
dc.contributor.googleauthor | Ji-Yong Moon | - |
dc.contributor.googleauthor | Seong Yong Lim | - |
dc.contributor.googleauthor | Kwang Ha Yoo | - |
dc.contributor.googleauthor | Joon Beom Seo | - |
dc.contributor.googleauthor | Yeon-Mok Oh | - |
dc.contributor.googleauthor | Sang-Do Lee | - |
dc.contributor.googleauthor | Yong Bum Park | - |
dc.identifier.doi | 10.1016/j.rmed.2020.105890 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J02615 | - |
dc.identifier.eissn | 1532-3064 | - |
dc.identifier.pmid | 32056836 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0954611120300305 | - |
dc.subject.keyword | Chronic obstructive pulmonary disease | - |
dc.subject.keyword | Emphysema | - |
dc.subject.keyword | Vitamin D | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 163 | - |
dc.citation.startPage | 105890 | - |
dc.identifier.bibliographicCitation | RESPIRATORY MEDICINE, Vol.163 : 105890, 2020-03 | - |
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