92 131

Cited 0 times in

Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

 Ki-Bum Won  ;  Eun Ji Park  ;  Donghee Han  ;  Ji Hyun Lee  ;  Su-Yeon Choi  ;  Eun Ju Chun  ;  Sung Hak Park  ;  Hae-Won Han  ;  Jidong Sung  ;  Hae Ok Jung  ;  Hyuk-Jae Chang 
 CARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 34, 2020-03 
Journal Title
Issue Date
Adult ; Biomarkers / blood ; Blood Glucose / analysis* ; Coronary Artery Disease / blood* ; Coronary Artery Disease / diagnostic imaging ; Coronary Artery Disease / epidemiology ; Disease Progression ; Fasting / blood ; Female ; Humans ; Incidence ; Insulin Resistance ; Longitudinal Studies ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Registries ; Republic of Korea / epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Triglycerides / blood* ; Vascular Calcification / blood* ; Vascular Calcification / diagnostic imaging ; Vascular Calcification / epidemiology
Atherosclerosis ; Coronary artery calcification ; Insulin resistance ; Triglyceride glucose index
Background: Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults.

Methods: We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period.

Results: During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100.

Conclusion: The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.
Files in This Item:
T202002220.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Won, Ki Bum(원기범)
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Han, Donghee(한동희)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.