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Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

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dc.contributor.author장혁재-
dc.contributor.author한동희-
dc.contributor.author원기범-
dc.date.accessioned2020-09-28T01:30:33Z-
dc.date.available2020-09-28T01:30:33Z-
dc.date.issued2020-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179032-
dc.description.abstractBackground: Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults. Methods: We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. Results: During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100. Conclusion: The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers / blood-
dc.subject.MESHBlood Glucose / analysis*-
dc.subject.MESHCoronary Artery Disease / blood*-
dc.subject.MESHCoronary Artery Disease / diagnostic imaging-
dc.subject.MESHCoronary Artery Disease / epidemiology-
dc.subject.MESHDisease Progression-
dc.subject.MESHFasting / blood-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTime Factors-
dc.subject.MESHTriglycerides / blood*-
dc.subject.MESHVascular Calcification / blood*-
dc.subject.MESHVascular Calcification / diagnostic imaging-
dc.subject.MESHVascular Calcification / epidemiology-
dc.titleTriglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorEun Ji Park-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorSu-Yeon Choi-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorSung Hak Park-
dc.contributor.googleauthorHae-Won Han-
dc.contributor.googleauthorJidong Sung-
dc.contributor.googleauthorHae Ok Jung-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1186/s12933-020-01008-5-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmid32178666-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCoronary artery calcification-
dc.subject.keywordInsulin resistance-
dc.subject.keywordTriglyceride glucose index-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage34-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 34, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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