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Serpina3c Regulates Adipogenesis by Modulating Insulin Growth Factor 1 and Integrin Signaling

DC FieldValueLanguage
dc.contributor.author윤보경-
dc.contributor.author김재우-
dc.contributor.author석조운-
dc.contributor.author김재우-
dc.contributor.author석조운-
dc.date.accessioned2020-09-28T01:29:46Z-
dc.date.available2020-09-28T01:29:46Z-
dc.date.issued2020-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179025-
dc.description.abstractPreadipocyte differentiation can be induced upon a hormonal treatment, and various factors secreted by the cells may contribute to adipogenesis. In this study, RNA-seq revealed Serpina3c as a critical factor regulating the signaling network during adipogenesis. Serpina3c is a secretory protein and is highly expressed in fat tissues. Knockdown of Serpina3c decreased adipogenesis by attenuating the mitotic clonal expansion of 3T3-L1 cells. These cells exhibited decreases in integrin α5, which abolished the phosphorylation of integrin β3. We found that Serpina3c inhibits a serine protease that regulates integrin α5 degradation. Knockdown of Serpina3c disrupted integrin-mediated insulin growth factor 1 (IGF-1) signaling and ERK activation. Serpina3c-mediated regulation of integrin-IGF-1 signaling is also associated with AKT activation, which affects the nuclear translocation of GSK3β. Altogether, our results indicate that Serpina3c secreted from differentiating adipocytes inhibits serine proteases to modulate integrin/IGF-1-mediated ERK and AKT signaling and thus is a critical factor contributing to adipogenesis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfISCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSerpina3c Regulates Adipogenesis by Modulating Insulin Growth Factor 1 and Integrin Signaling-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorYoonjeong Choi-
dc.contributor.googleauthorHyeonjin Choi-
dc.contributor.googleauthorBo Kyung Yoon-
dc.contributor.googleauthorHyemin Lee-
dc.contributor.googleauthorJo Woon Seok-
dc.contributor.googleauthorHyo Jung Kim-
dc.contributor.googleauthorJae-Woo Kim-
dc.identifier.doi10.1016/j.isci.2020.100961-
dc.contributor.localIdA05928-
dc.contributor.localIdA00865-
dc.contributor.localIdA00865-
dc.contributor.localIdA05922-
dc.contributor.localIdA05922-
dc.contributor.localIdA00865-
dc.contributor.localIdA00865-
dc.contributor.localIdA05922-
dc.contributor.localIdA05922-
dc.relation.journalcodeJ03874-
dc.identifier.eissn2589-0042-
dc.identifier.pmid32193145-
dc.subject.keywordDevelopmental Biology-
dc.subject.keywordMolecular Biology-
dc.subject.keywordTranscriptomics-
dc.contributor.alternativeNameYoon, Bo Kyung-
dc.contributor.affiliatedAuthor윤보경-
dc.contributor.affiliatedAuthor김재우-
dc.contributor.affiliatedAuthor김재우-
dc.contributor.affiliatedAuthor석조운-
dc.contributor.affiliatedAuthor석조운-
dc.contributor.affiliatedAuthor김재우-
dc.contributor.affiliatedAuthor김재우-
dc.contributor.affiliatedAuthor석조운-
dc.contributor.affiliatedAuthor석조운-
dc.citation.volume23-
dc.citation.number3-
dc.citation.startPage100961-
dc.identifier.bibliographicCitationISCIENCE, Vol.23(3) : 100961, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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