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Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients

Authors
 Hyemin Jang  ;  Hee Jin Kim  ;  Seongbeom Park  ;  Yu Hyun Park  ;  Yeongsim Choe  ;  Hanna Cho  ;  Chul Hyoung Lyoo  ;  Uicheul Yoon  ;  Jin San Lee  ;  Yeshin Kim  ;  Seung Joo Kim  ;  Jun Pyo Kim  ;  Young Hee Jung  ;  Young Hoon Ryu  ;  Jae Yong Choi  ;  Seung Hwan Moon  ;  Joon-Kyung Seong  ;  Charles DeCarli  ;  Michael W Weiner  ;  Samuel N Lockhart  ;  Soo Hyun Cho  ;  Duk L Na  ;  Sang Won Seo 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.47(2) : 292-303, 2020-02 
Journal Title
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 
ISSN
 1619-7070 
Issue Date
2020-02
Keywords
Amyloid-β ; Classification ; Longitudinal changes ; Subcortical vascular cognitive impairment ; Tau
Abstract
Objective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer's disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A-/A+) and tau (T-/T+) based on PET results. Across the three SVCI groups (A-, A+T-, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A-, A+T-, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T-SVCI had steeper cognitive decline than A-SVCI. A+T+SVCI also showed steeper cognitive decline than A+T-SVCI. Also, A+T-SVCI had steeper decrease in HV than A-SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T-SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.
Full Text
https://link.springer.com/article/10.1007%2Fs00259-019-04498-y
DOI
10.1007/s00259-019-04498-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179012
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