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Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author조한나-
dc.contributor.author유영훈-
dc.contributor.author최재용-
dc.contributor.author조한나-
dc.contributor.author유영훈-
dc.contributor.author최재용-
dc.date.accessioned2020-09-28T01:28:03Z-
dc.date.available2020-09-28T01:28:03Z-
dc.date.issued2020-02-
dc.identifier.issn1619-7070-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179012-
dc.description.abstractObjective: To apply an AT (Aβ/tau) classification system to subcortical vascular cognitive impairment (SVCI) patients following recently developed biomarker-based criteria of Alzheimer's disease (AD), and to investigate its clinical significance. Methods: We recruited 60 SVCI patients who underwent the neuropsychological tests, brain MRI, and 18F-florbetaben and 18F-AV1451 PET at baseline. As a control group, we further recruited 27 patients with AD cognitive impairment (ADCI; eight Aβ PET-positive AD dementia and 19 amnestic mild cognitive impairment). ADCI and SVCI patients were classified as having normal or abnormal Aβ (A-/A+) and tau (T-/T+) based on PET results. Across the three SVCI groups (A-, A+T-, and A+T+SVCI), we compared longitudinal changes in cognition, hippocampal volume (HV), and cortical thickness using linear mixed models. Results: Among SVCI patients, 33 (55%), 20 (33.3%), and seven (11.7%) patients were A-, A+T-, and A+T+, respectively. The frequency of T+ was lower in A+SVCI (7/27, 25.9%) than in A+ADCI (14/20, 70.0%, p = 0.003) which suggested that cerebral small vessel disease affected cognitive impairments independently of A+. A+T-SVCI had steeper cognitive decline than A-SVCI. A+T+SVCI also showed steeper cognitive decline than A+T-SVCI. Also, A+T-SVCI had steeper decrease in HV than A-SVCI, while cortical thinning did not differ between the two groups. A+T+SVCI had greater global cortical thinning compared with A+T-SVCI, while declines in HV did not differ between the two groups. Conclusion: This study showed that the AT system successfully characterized SVCI patients, suggesting that the AT system may be usefully applied in a research framework for clinically diagnosed SVCI.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag Berlin-
dc.relation.isPartOfEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleApplication of an amyloid and tau classification system in subcortical vascular cognitive impairment patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHyemin Jang-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorSeongbeom Park-
dc.contributor.googleauthorYu Hyun Park-
dc.contributor.googleauthorYeongsim Choe-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorUicheul Yoon-
dc.contributor.googleauthorJin San Lee-
dc.contributor.googleauthorYeshin Kim-
dc.contributor.googleauthorSeung Joo Kim-
dc.contributor.googleauthorJun Pyo Kim-
dc.contributor.googleauthorYoung Hee Jung-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorSeung Hwan Moon-
dc.contributor.googleauthorJoon-Kyung Seong-
dc.contributor.googleauthorCharles DeCarli-
dc.contributor.googleauthorMichael W Weiner-
dc.contributor.googleauthorSamuel N Lockhart-
dc.contributor.googleauthorSoo Hyun Cho-
dc.contributor.googleauthorDuk L Na-
dc.contributor.googleauthorSang Won Seo-
dc.identifier.doi10.1007/s00259-019-04498-y-
dc.contributor.localIdA01333-
dc.contributor.localIdA03920-
dc.contributor.localIdA03920-
dc.contributor.localIdA02485-
dc.contributor.localIdA02485-
dc.contributor.localIdA04695-
dc.contributor.localIdA04695-
dc.contributor.localIdA03920-
dc.contributor.localIdA03920-
dc.contributor.localIdA02485-
dc.contributor.localIdA02485-
dc.contributor.localIdA04695-
dc.contributor.localIdA04695-
dc.relation.journalcodeJ00833-
dc.identifier.eissn1619-7089-
dc.identifier.pmid31471715-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00259-019-04498-y-
dc.subject.keywordAmyloid-β-
dc.subject.keywordClassification-
dc.subject.keywordLongitudinal changes-
dc.subject.keywordSubcortical vascular cognitive impairment-
dc.subject.keywordTau-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthor류철형-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor최재용-
dc.contributor.affiliatedAuthor최재용-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor최재용-
dc.contributor.affiliatedAuthor최재용-
dc.citation.volume47-
dc.citation.number2-
dc.citation.startPage292-
dc.citation.endPage303-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.47(2) : 292-303, 2020-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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