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Effects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial

Authors
 Jae Hoon Chung  ;  Kyu Shik Kim  ;  Jae Duck Choi  ;  Tae Hyo Kim  ;  Ki Soo Lee  ;  Cheol Young Oh  ;  Joon Hwa Noh  ;  Jun Seok Kim  ;  Won Tae Kim  ;  Seung Hwan Lee  ;  Jae Heon Kim  ;  Tae Nam Kim  ;  Wan Huh  ;  Seung Wook Lee 
Citation
 BJU INTERNATIONAL, Vol.125(1) : 160-167, 2020-01 
Journal Title
BJU INTERNATIONAL
ISSN
 1464-4096 
Issue Date
2020-01
MeSH
Aged ; Gels ; Humans ; Instillation, Drug ; Male ; Middle Aged ; Poloxamer* ; Postoperative Complications / prevention & control* ; Prospective Studies ; Prostatic Hyperplasia / surgery* ; Single-Blind Method ; Temperature ; Transurethral Resection of Prostate* ; Treatment Outcome ; Urethral Stricture / prevention & control*
Keywords
UroBPH ; chitosan ; gelatine ; poloxamer ; prostatic hyperplasia ; transurethral resection of prostate ; urethral stricture
Abstract
Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol-gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture.

Patients and methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax ), post-void residual urine volume (PVR), and cystoscopy.

Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023).

Conclusions: Poloxamer-based thermo-sensitive sol-gel instillation after TURP lowered the incidence of urethral stricture.
Full Text
https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.14902
DOI
10.1111/bju.14902
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hwan(이승환) ORCID logo https://orcid.org/0000-0001-7358-8544
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178990
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