Cited 7 times in
Effects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial
DC Field | Value | Language |
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dc.contributor.author | 이승환 | - |
dc.date.accessioned | 2020-09-28T00:56:08Z | - |
dc.date.available | 2020-09-28T00:56:08Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1464-4096 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178990 | - |
dc.description.abstract | Objective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol-gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax ), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol-gel instillation after TURP lowered the incidence of urethral stricture. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Science | - |
dc.relation.isPartOf | BJU INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Gels | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Instillation, Drug | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Poloxamer* | - |
dc.subject.MESH | Postoperative Complications / prevention & control* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Prostatic Hyperplasia / surgery* | - |
dc.subject.MESH | Single-Blind Method | - |
dc.subject.MESH | Temperature | - |
dc.subject.MESH | Transurethral Resection of Prostate* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Urethral Stricture / prevention & control* | - |
dc.title | Effects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Jae Hoon Chung | - |
dc.contributor.googleauthor | Kyu Shik Kim | - |
dc.contributor.googleauthor | Jae Duck Choi | - |
dc.contributor.googleauthor | Tae Hyo Kim | - |
dc.contributor.googleauthor | Ki Soo Lee | - |
dc.contributor.googleauthor | Cheol Young Oh | - |
dc.contributor.googleauthor | Joon Hwa Noh | - |
dc.contributor.googleauthor | Jun Seok Kim | - |
dc.contributor.googleauthor | Won Tae Kim | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Jae Heon Kim | - |
dc.contributor.googleauthor | Tae Nam Kim | - |
dc.contributor.googleauthor | Wan Huh | - |
dc.contributor.googleauthor | Seung Wook Lee | - |
dc.identifier.doi | 10.1111/bju.14902 | - |
dc.contributor.localId | A02938 | - |
dc.relation.journalcode | J00340 | - |
dc.identifier.eissn | 1464-410X | - |
dc.identifier.pmid | 31444917 | - |
dc.identifier.url | https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.14902 | - |
dc.subject.keyword | UroBPH | - |
dc.subject.keyword | chitosan | - |
dc.subject.keyword | gelatine | - |
dc.subject.keyword | poloxamer | - |
dc.subject.keyword | prostatic hyperplasia | - |
dc.subject.keyword | transurethral resection of prostate | - |
dc.subject.keyword | urethral stricture | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | 이승환 | - |
dc.citation.volume | 125 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 160 | - |
dc.citation.endPage | 167 | - |
dc.identifier.bibliographicCitation | BJU INTERNATIONAL, Vol.125(1) : 160-167, 2020-01 | - |
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