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Effects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial

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dc.contributor.author이승환-
dc.date.accessioned2020-09-28T00:56:08Z-
dc.date.available2020-09-28T00:56:08Z-
dc.date.issued2020-01-
dc.identifier.issn1464-4096-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178990-
dc.description.abstractObjective: To evaluate the effectiveness of poloxamer-based thermo-sensitive sol-gel instillation, after transurethral resection of the prostate (TURP), for preventing urethral stricture. Patients and methods: In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer-based thermo-sensitive sol-gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP. Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer-based thermo-sensitive sol-gel instillation was evaluated based on the International Prostate Symptom Score (IPSS), IPSS-Quality of Life (QoL), Overactive bladder questionnaire (OAB-q), maximum urinary flow rate (Qmax ), post-void residual urine volume (PVR), and cystoscopy. Results: Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS-QoL and OAB-q between the groups. However, Qmax was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL/s (P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B (P = 0.023). Conclusions: Poloxamer-based thermo-sensitive sol-gel instillation after TURP lowered the incidence of urethral stricture.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Science-
dc.relation.isPartOfBJU INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHGels-
dc.subject.MESHHumans-
dc.subject.MESHInstillation, Drug-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPoloxamer*-
dc.subject.MESHPostoperative Complications / prevention & control*-
dc.subject.MESHProspective Studies-
dc.subject.MESHProstatic Hyperplasia / surgery*-
dc.subject.MESHSingle-Blind Method-
dc.subject.MESHTemperature-
dc.subject.MESHTransurethral Resection of Prostate*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUrethral Stricture / prevention & control*-
dc.titleEffects of poloxamer-based thermo-sensitive sol-gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single-blinded, randomised controlled trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorJae Hoon Chung-
dc.contributor.googleauthorKyu Shik Kim-
dc.contributor.googleauthorJae Duck Choi-
dc.contributor.googleauthorTae Hyo Kim-
dc.contributor.googleauthorKi Soo Lee-
dc.contributor.googleauthorCheol Young Oh-
dc.contributor.googleauthorJoon Hwa Noh-
dc.contributor.googleauthorJun Seok Kim-
dc.contributor.googleauthorWon Tae Kim-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorJae Heon Kim-
dc.contributor.googleauthorTae Nam Kim-
dc.contributor.googleauthorWan Huh-
dc.contributor.googleauthorSeung Wook Lee-
dc.identifier.doi10.1111/bju.14902-
dc.contributor.localIdA02938-
dc.relation.journalcodeJ00340-
dc.identifier.eissn1464-410X-
dc.identifier.pmid31444917-
dc.identifier.urlhttps://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.14902-
dc.subject.keywordUroBPH-
dc.subject.keywordchitosan-
dc.subject.keywordgelatine-
dc.subject.keywordpoloxamer-
dc.subject.keywordprostatic hyperplasia-
dc.subject.keywordtransurethral resection of prostate-
dc.subject.keywordurethral stricture-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.affiliatedAuthor이승환-
dc.citation.volume125-
dc.citation.number1-
dc.citation.startPage160-
dc.citation.endPage167-
dc.identifier.bibliographicCitationBJU INTERNATIONAL, Vol.125(1) : 160-167, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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