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Efficacy of risedronate with cholecalciferol on bone mineral density in Korean patients with osteoporosis

Authors
 So Young Park  ;  Moo-Il Kang  ;  Hyung Moo Park  ;  Yumie Rhee  ;  Seong Hwan Moon  ;  Hyun Koo Yoon  ;  Jung-Min Koh  ;  Jae Suk Chang  ;  In Joo Kim  ;  Ye Yeon Won  ;  Ye Soo Park  ;  Hoon Choi  ;  Chan Soo Shin  ;  Taek Rim Yoon  ;  Sung-Cheol Yun  ;  Ho-Yeon Chung  ;  IDEAL Trial Investigators 
Citation
 ARCHIVES OF OSTEOPOROSIS, Vol.15(1) : 3, 2019-12 
Journal Title
 ARCHIVES OF OSTEOPOROSIS 
ISSN
 1862-3522 
Issue Date
2019-12
Keywords
Bone mineral density ; Cholecalciferol ; Osteoporosis ; Risedronic acid
Abstract
The efficacy of once-weekly risedronate with and without cholecalciferol in bone mineral density (BMD) in Korean patients with osteoporosis was compared. After 12 months, both spine and hip BMD increased significantly in both groups, but there was no significant difference between two groups. Introduction: This study investigated the efficacy and safety of once-weekly risedronate with and without cholecalciferol in BMD in Korean patients with osteoporosis. Methods: This was a prospective, 12-month, randomized, open-labeled, actively controlled trial involving 41 hospitals. A total of 841 subjects with osteoporosis were randomized to once-weekly risedronate (35 mg) and cholecalciferol (5600 IU) in a single pill (RSD+, n = 642) or once-weekly risedronate (35 mg) alone (RSD, n = 199). BMD was measured via dual-energy X-ray absorptiometry at the lumbar spine and hip, and the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), and alkaline phosphatase (ALP) were assayed at baseline and after 12 months of treatment. Results: After 12 months, the lumbar spine, femoral neck, and total hip BMD increased significantly in both groups; there was no significant difference between two groups. Women in the RSD+ group exhibited significantly increased lumbar spine BMD, and subjects with previous fracture history in the RSD+ group had significantly increased total hip BMD compared with the RSD group. The serum 25(OH) D level increased significantly in the RSD+ group. The serum PTH level decreased in the RSD+ group but increased in the RSD group. The serum ALP level significantly decreased in both groups; there was no significant difference between two groups. Conclusions: A once-weekly pill containing risedronate and cholecalciferol had the equivalent antiresorptive efficacy on BMD compared with risedronate alone and improved 25(OH) D serum levels after 12 months of treatment without significant adverse events in Korean patients with osteoporosis.
Full Text
https://link.springer.com/article/10.1007%2Fs11657-019-0663-5
DOI
10.1007/s11657-019-0663-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seong Hwan(문성환)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178926
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