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Efficacy of risedronate with cholecalciferol on bone mineral density in Korean patients with osteoporosis

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dc.contributor.author문성환-
dc.contributor.author이유미-
dc.date.accessioned2020-09-07T06:50:41Z-
dc.date.available2020-09-07T06:50:41Z-
dc.date.issued2019-12-
dc.identifier.issn1862-3522-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178926-
dc.description.abstractThe efficacy of once-weekly risedronate with and without cholecalciferol in bone mineral density (BMD) in Korean patients with osteoporosis was compared. After 12 months, both spine and hip BMD increased significantly in both groups, but there was no significant difference between two groups. Introduction: This study investigated the efficacy and safety of once-weekly risedronate with and without cholecalciferol in BMD in Korean patients with osteoporosis. Methods: This was a prospective, 12-month, randomized, open-labeled, actively controlled trial involving 41 hospitals. A total of 841 subjects with osteoporosis were randomized to once-weekly risedronate (35 mg) and cholecalciferol (5600 IU) in a single pill (RSD+, n = 642) or once-weekly risedronate (35 mg) alone (RSD, n = 199). BMD was measured via dual-energy X-ray absorptiometry at the lumbar spine and hip, and the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), and alkaline phosphatase (ALP) were assayed at baseline and after 12 months of treatment. Results: After 12 months, the lumbar spine, femoral neck, and total hip BMD increased significantly in both groups; there was no significant difference between two groups. Women in the RSD+ group exhibited significantly increased lumbar spine BMD, and subjects with previous fracture history in the RSD+ group had significantly increased total hip BMD compared with the RSD group. The serum 25(OH) D level increased significantly in the RSD+ group. The serum PTH level decreased in the RSD+ group but increased in the RSD group. The serum ALP level significantly decreased in both groups; there was no significant difference between two groups. Conclusions: A once-weekly pill containing risedronate and cholecalciferol had the equivalent antiresorptive efficacy on BMD compared with risedronate alone and improved 25(OH) D serum levels after 12 months of treatment without significant adverse events in Korean patients with osteoporosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfARCHIVES OF OSTEOPOROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEfficacy of risedronate with cholecalciferol on bone mineral density in Korean patients with osteoporosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorSo Young Park-
dc.contributor.googleauthorMoo-Il Kang-
dc.contributor.googleauthorHyung Moo Park-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorSeong Hwan Moon-
dc.contributor.googleauthorHyun Koo Yoon-
dc.contributor.googleauthorJung-Min Koh-
dc.contributor.googleauthorJae Suk Chang-
dc.contributor.googleauthorIn Joo Kim-
dc.contributor.googleauthorYe Yeon Won-
dc.contributor.googleauthorYe Soo Park-
dc.contributor.googleauthorHoon Choi-
dc.contributor.googleauthorChan Soo Shin-
dc.contributor.googleauthorTaek Rim Yoon-
dc.contributor.googleauthorSung-Cheol Yun-
dc.contributor.googleauthorHo-Yeon Chung-
dc.contributor.googleauthorIDEAL Trial Investigators-
dc.identifier.doi10.1007/s11657-019-0663-5-
dc.contributor.localIdA01365-
dc.contributor.localIdA03012-
dc.relation.journalcodeJ03447-
dc.identifier.eissn1862-3514-
dc.identifier.pmid31820121-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11657-019-0663-5-
dc.subject.keywordBone mineral density-
dc.subject.keywordCholecalciferol-
dc.subject.keywordOsteoporosis-
dc.subject.keywordRisedronic acid-
dc.contributor.alternativeNameMoon, Seong Hwan-
dc.contributor.affiliatedAuthor문성환-
dc.contributor.affiliatedAuthor이유미-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage3-
dc.identifier.bibliographicCitationARCHIVES OF OSTEOPOROSIS, Vol.15(1) : 3, 2019-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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