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Current concepts in the immunopathogenesis of psoriasis

Authors
 Michelle A Lowes  ;  Wook Lew  ;  James G Krueger 
Citation
 DERMATOLOGIC CLINICS, Vol.22(4) : 349-369, 2004-10 
Journal Title
 DERMATOLOGIC CLINICS 
ISSN
 0733-8635 
Issue Date
2004-10
MeSH
Animals ; Biopsy, Needle ; Cytokines / immunology* ; Cytokines / metabolism ; Disease Models, Animal ; Disease Progression ; Female ; Humans ; Immunity, Innate / physiology* ; Immunohistochemistry ; Male ; Prognosis ; Psoriasis / immunology* ; Psoriasis / pathology* ; Rats ; Sensitivity and Specificity
Abstract
There is much evidence to support the concept that psoriasis is a type 1 autoimmune disease, primarily mediated by interferon gamma and other inflammatory cytokines. There has been renewed interest in the role of components of the innate immune system, however,and it may be that overlap between the innate and acquired arms of the immune system can better explain immunopathogenesis in psoriasis. Relevant cell types, receptors, and immune mediators within these traditional boundaries of the immune system are discussed.Finally, pathogenic contributions from important psoriatic mouse models and recent genomic data using the new gene chip technology are elaborated.
Full Text
https://www.sciencedirect.com/science/article/abs/pii/S0733863504000191
DOI
10.1016/j.det.2004.03.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lew, Wook(유욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178871
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