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백서 두개골 실험적 결손부에서 Para-Dioxanone 차단막의 골조직 재생 효과

Other Titles
 The Bone Regenerative Effects of Paradioxanone on the Calvarial Critical Size Defect in Sprague Dawley Rats 
 권석훈  ;  석헌주  ;  김종관  ;  정한성  ;  문익상 
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.33(1) : 61-77, 2003-03 
Journal Title
Journal of Korean Academy of Periodontology(대한치주과학회지)
Issue Date
The major goals of periodontal therapy are the functional regeneration of periodontal supporting structures
already destructed by periodontal disease as well as the reduction of signs and symptoms of progressive periodontal
disease. There have been many efforts to develop materials and therapeutic methods to promote periodontal
wound healing. Bone graft & guided tissue are being used for the regeneration of destroyed periodontium
these days. Non-resorbable membranes were used for Guided tissue regeneration in early days, however
more researches are focused on resorbable membranes these days.
The aim of this study is to evaluate the osteogenesis of paradioxanone membrane on the calvarial critical size
defect in Sprague Dawley rats. An 8 mm diameter surgical defect was produced with a trephine bur in the area
of the midsagittal suture. The rats were divided into three groups: Untreated control group, Biomesh􄠶 group
and paradioxanone group. The animals were sacrificed at 4, 8 and 12 weeks after surgical procedure. The
specimens were examined by histologic, histomorphometric analyses. The results are as follows:
1. In histological view on Biomesh􄠶, no visible signs of resorption was observed at 4 weeks but progressive
resorption was observed at 8 weeks through 12 weeks. Paradioxanone membrane expanded at 4 weeks,
and rapid resorption was observed at 8 weeks. In both the membranes, inflammatory cells were observed
around them. Inflammatory cells decreased with time but were still present at 12 weeks. More inflammatory
cells were observed in paradioxanone membranes than in Biomesh􄠶 membrane.
2. The area of newly formed bone in the defects were 0.001±0.001, 0.006±0.005, 0.002±0.003 at the 4
weeks, 0.021±0.020, 0.133±0.073, 0.118±0.070 at the 8 weeks and 0.163±0.067, 0.500±0.197, 0.487±
0.214 at the 12 weeks in the control group, Biomesh􄠶 group and experimental group respectively.
Compared to the control group, Biomesh􄠶 group displayed significant differences at 4,8, and 12 weeks
and the paradioxanone group at 8 and 12 weeks.(P<0.05)
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Moon, Ik Sang(문익상)
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