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Dopaminergic influence on disturbed spatial discrimination in Parkinson's disease

Authors
 Hae-Won Shin  ;  Suk Y Kang  ;  Young H Sohn 
Citation
 MOVEMENT DISORDERS, Vol.20(12) : 1640-1643, 2005-12 
Journal Title
 MOVEMENT DISORDERS 
ISSN
 0885-3185 
Issue Date
2005-12
MeSH
Antiparkinson Agents / adverse effects* ; Antiparkinson Agents / therapeutic use ; Case-Control Studies ; Discrimination, Psychological / drug effects ; Dopamine / metabolism* ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease / drug therapy ; Parkinson Disease / physiopathology* ; Perceptual Disorders / etiology* ; Space Perception / physiology* ; Time Factors
Abstract
Various sensory symptoms and disturbed sensory perception are often observed in patients with idiopathic Parkinson's disease (PD). The basis of sensory disturbance in PD is unknown but possibly reflects a role for the basal ganglia in sensory processing. To investigate the relationship between the sensory dysfunction and dopaminergic deficiency in PD, we measured spatial discrimination using the Grating Orientation Task in 21 drug-naive patients with PD, before and after long-term antiparkinson therapy, and 25 age-matched healthy controls. The grating orientation threshold was significantly higher in patients (3.03 +/- 0.84) than controls (2.03 +/- 0.79). After 3 to 10 months of antiparkinson therapy, the grating orientation threshold was significantly lowered (2.66 +/- 0.84), although it was still higher than that in controls. Improvement in the patients' sensory function was significantly correlated with motor improvement (r = 0.44). These results suggest that sensory dysfunction in Parkinson's disease is related at least in part to the dopaminergic deficit.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/mds.20642
DOI
10.1002/mds.20642
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178854
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