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Dopaminergic influence on disturbed spatial discrimination in Parkinson's disease

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dc.contributor.author손영호-
dc.date.accessioned2020-09-04T02:10:51Z-
dc.date.available2020-09-04T02:10:51Z-
dc.date.issued2005-12-
dc.identifier.issn0885-3185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178854-
dc.description.abstractVarious sensory symptoms and disturbed sensory perception are often observed in patients with idiopathic Parkinson's disease (PD). The basis of sensory disturbance in PD is unknown but possibly reflects a role for the basal ganglia in sensory processing. To investigate the relationship between the sensory dysfunction and dopaminergic deficiency in PD, we measured spatial discrimination using the Grating Orientation Task in 21 drug-naive patients with PD, before and after long-term antiparkinson therapy, and 25 age-matched healthy controls. The grating orientation threshold was significantly higher in patients (3.03 +/- 0.84) than controls (2.03 +/- 0.79). After 3 to 10 months of antiparkinson therapy, the grating orientation threshold was significantly lowered (2.66 +/- 0.84), although it was still higher than that in controls. Improvement in the patients' sensory function was significantly correlated with motor improvement (r = 0.44). These results suggest that sensory dysfunction in Parkinson's disease is related at least in part to the dopaminergic deficit.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfMOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntiparkinson Agents / adverse effects*-
dc.subject.MESHAntiparkinson Agents / therapeutic use-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDiscrimination, Psychological / drug effects-
dc.subject.MESHDopamine / metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease / drug therapy-
dc.subject.MESHParkinson Disease / physiopathology*-
dc.subject.MESHPerceptual Disorders / etiology*-
dc.subject.MESHSpace Perception / physiology*-
dc.subject.MESHTime Factors-
dc.titleDopaminergic influence on disturbed spatial discrimination in Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHae-Won Shin-
dc.contributor.googleauthorSuk Y Kang-
dc.contributor.googleauthorYoung H Sohn-
dc.identifier.doi10.1002/mds.20642-
dc.contributor.localIdA01982-
dc.relation.journalcodeJ02275-
dc.identifier.eissn1531-8257-
dc.identifier.pmid16092109-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/mds.20642-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.citation.volume20-
dc.citation.number12-
dc.citation.startPage1640-
dc.citation.endPage1643-
dc.identifier.bibliographicCitationMOVEMENT DISORDERS, Vol.20(12) : 1640-1643, 2005-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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