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Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain

Authors
 Sung Tae Kim  ;  Jin Woo Chang  ;  Hea Nam Hong  ;  Onyou Hwang 
Citation
 NEUROSCIENCE LETTERS, Vol.359(1-2) : 69-72, 2004-04 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2004-04
MeSH
Animals ; Biopterin / administration & dosage* ; Biopterin / analogs & derivatives* ; Brain / drug effects ; Brain / metabolism ; Brain / pathology ; Corpus Striatum / drug effects* ; Corpus Striatum / metabolism ; Corpus Striatum / pathology ; Dopamine / metabolism* ; Injections, Intraventricular ; Nerve Fibers / drug effects* ; Nerve Fibers / metabolism ; Nerve Fibers / pathology ; Rats
Abstract
We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304394004001843
DOI
10.1016/j.neulet.2004.02.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178813
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