Cited 12 times in
Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain
DC Field | Value | Language |
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dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2020-09-04T02:06:44Z | - |
dc.date.available | 2020-09-04T02:06:44Z | - |
dc.date.issued | 2004-04 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178813 | - |
dc.description.abstract | We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells. We report in the present study that BH4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (TH) immunopositive fibers, a decreased amount of TH protein, and decreased dopamine content. Thus, the results of our study further provide evidence that BH4, the molecule endogenously present in the dopaminergic neurons, may participate in the nigrostriatal degeneration as in Parkinson's disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers Ireland | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biopterin / administration & dosage* | - |
dc.subject.MESH | Biopterin / analogs & derivatives* | - |
dc.subject.MESH | Brain / drug effects | - |
dc.subject.MESH | Brain / metabolism | - |
dc.subject.MESH | Brain / pathology | - |
dc.subject.MESH | Corpus Striatum / drug effects* | - |
dc.subject.MESH | Corpus Striatum / metabolism | - |
dc.subject.MESH | Corpus Striatum / pathology | - |
dc.subject.MESH | Dopamine / metabolism* | - |
dc.subject.MESH | Injections, Intraventricular | - |
dc.subject.MESH | Nerve Fibers / drug effects* | - |
dc.subject.MESH | Nerve Fibers / metabolism | - |
dc.subject.MESH | Nerve Fibers / pathology | - |
dc.subject.MESH | Rats | - |
dc.title | Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Sung Tae Kim | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.contributor.googleauthor | Hea Nam Hong | - |
dc.contributor.googleauthor | Onyou Hwang | - |
dc.identifier.doi | 10.1016/j.neulet.2004.02.015 | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 15050714 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304394004001843 | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | 장진우 | - |
dc.citation.volume | 359 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.359(1-2) : 69-72, 2004-04 | - |
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